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MetabolomicsThe Human Saliva Metabolome
Saliva is composed of a variety of molecules that modulate the oral cavity. It is mainly composed of water (95%) and several minor components such as electrolytes, proteins, and low molecular weight compounds. It consists of metabolites from drinks, foods, drugs, environmental contaminants, and bact...
2015-09-01 | MTBLS100 | MetaboLights
MetabolomicsHuman age-declined saliva metabolic markers determined by LC-MS

Metabolites in human biofluids reflect individual physiological body states influenced by various factors. Using liquid chromatography-mass spectrometry (LC-MS), we conducted non-targeted, non-invasive, comprehensive metabolomics using saliva of 27 healthy volunteers in Okinawa, consisting of 13 ...

2021-02-11 | MTBLS2108 | MetaboLights
MetabolomicsVolatilomic insight of head and neck cancer via the effects observed on saliva metabolites
Head and neck cancer (HNC) is a heterogeneous malignant disease with distinct global distribution. Metabolic adaptations of HNC are significantly gaining clinical interests nowadays. Here, we investigated effects of HNC on differential expression of volatile metabolites in human saliva. We applied h...
2019-06-03 | MTBLS760 | MetaboLights
MetabolomicsIdentification of a discriminative metabolomic fingerprint of potential clinical relevance in saliva of patients with periodontitis using 1H nuclear magnetic resonance (NMR) spectroscopy
Periodontitis is characterized by the loss of the supporting tissues of the teeth in an inflammatory-infectious context. The diagnosis relies on clinical and X-ray examination. Unfortunately, clinical signs of tissue destruction occur late in the disease progression. Therefore, it is mandatory to id...
2018-08-14 | MTBLS524 | MetaboLights
MetabolomicsPolymicrobial detection and metabolomics in saliva of children with early childhood caries

Cariogenic microorganisms as well as salivary metabolic status in early childhood caries (ECC) have been reported to differ from that in adult caries. The main aim of this study was to identify specific microbial species and salivary metabolites in children with ECC using species-specific qPCR an...

2024-11-12 | MTBLS10890 | MetaboLights
TranscriptomicsDetermination of transcriptome of SptR in group A Streptococcus during growth in human saliva
The molecular genetic mechanisms used by bacteria to persist in humans are poorly understood. Group A Streptococcus (GAS) causes the majority of bacterial pharyngitis cases in humans and is prone to persistently inhabit the upper respiratory tract. To gain information about how GAS survives in and i...
ORGANISM(S): Streptococcus sp. 'group A' 
2010-05-19 | E-GEOD-16124 | biostudies-arrayexpress
MetabolomicsSaliva metabolome and microbiome in permanent teeth caries

Metabolites are important determinants of disease progression. In this study, we conducted a case-control study to explore permanent teeth caries-related differences in salivary metabolite profiles and related changes in the composition of the oral microbiota in 200 subjects including 100 caries-...

2024-05-14 | MTBLS4569 | MetaboLights
TranscriptomicsProfile the RNA composition of cell-free saliva and salivary exosomes
We compared the transcriptomic content of salivary exosomes vs. whole saliva via microarray (Affymetrix HU133 plus 2.0). Unstimulated saliva samples and derived exosome-like microvesicles were obtained from 3 healthy volunteers and processed for RNA isolation and microarray analysis.
ORGANISM(S): Homo sapiens 
2014-09-10 | E-GEOD-50700 | biostudies-arrayexpress
MetabolomicsA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data ...
2018-05-16 | MTBLS656 | MetaboLights
TranscriptomicsDevelopment of Transcriptomic Biomarker Signature in Human Saliva to Detect Lung Cancer
Affymetrix HG U133 Plus 2.0 Array (Affymetrix, Santa Clara, CA) was used to profile transcriptomes and discover altered gene expression in saliva supernatant. Salivary transcriptomic biomarker discovery was performed on 10 lung cancer patients and 10 matched controls. Seven messenger RNA biomarkers ...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-32175 | biostudies-arrayexpress
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