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GenomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (ChIP-Seq)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-60223 | biostudies-arrayexpress
TranscriptomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (array)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-60175 | biostudies-arrayexpress
ProteomicsMudPIT analysis of S. pombe proteins interacting with Pof8
To identify proteins interacting with Pof8, cell-free extracts of strains FP1547 harboring 3xFLAG epitope-tagged Pof8 and untagged control (FP1546) were diluted to 5 mg/ml in 8 ml of lysis buffer (50 mM Tris-HCl pH 7.5, 150 mM sodium chloride, 0.1% (v/v) NP40 and 10% (v/v) glycerol) plus complete ED...
ORGANISM(S): Schizosaccharomyces Pombe (ncbitaxon:4896) 
2021-05-24 | MSV000087493 | MassIVE
GenomicsEnhanced cardiac repair by human telomerase reverse transcriptase over-expression in human cardiac mesenchymal stem cells
Enhanced cardiac repair by human telomerase reverse transcriptase over-expression in human cardiac mesenchymal stem cells
PRJNA445555 | ENA
TranscriptomicsTranscription profiling of human CD* T lymphocytes overexpressing hTERT
Using CD8+ T lymphocyte clones over-expressing telomerase weinvestigated the molecular mechanisms that regulate T cell proliferation. Transduction and subcloning procedures were performed on CD8 + naive T-cell clones isolated from two different healthy individuals aged between 30 to 35 years (HD1 a...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5143 | biostudies-arrayexpress
ProteomicsMass spectrum for identifying the interacting proteins of telomerase reverse transcriptase
The 293T cells overexpressing human telomerase reverse transcriptase (hTERT) were lysed and co-immunoprecipitation was performed using hTERT antibody. Then protein mass spectrum was conducted in order to identify the hTERT-interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD048859 | Pride
Chemoresistance Mt-nd1 Mitochondrial htert Glucose metabolism 
TranscriptomicsTranscription profiling of human CD8 T lymphocytes from two healthy donors transduced with hTERT
Expression in GFP vs. GFP/hTERT transduced CD8 T Lymphocytes from Healty Donors (HD) 1 and 2 at early and late passages. Using CD8+ T lymphocyte clones over-expressing telomerase weinvestigated the molecular mechanisms that regulate T cell proliferation. Transduction and subcloning procedures were p...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5144 | biostudies-arrayexpress
GenomicsTelomerase activation by genomic rearrangements in high-risk neuroblastoma
Neuroblastoma is a malignant pediatric tumor of the sympathetic nervous system1. Roughly half of these tumors regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavorable clinical course despite intensive multimodal treatment, and their molecular b...
EGAS00001001308 | EGA
TranscriptomicsTranscription profiling of gulahuman CD8 T lyphocytes overexpressing hTERT to investigate regulation of profileration
Using CD8+ T lymphocyte clones over-expressing telomerase weinvestigated the molecular mechanisms that regulate T cell proliferation. Transduction and subcloning procedures were performed on CD8 + naive T-cell clones isolated from two different healthy individuals aged between 30 to 35 years (HD1 a...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5142 | biostudies-arrayexpress
TranscriptomicsEnhanced cardiac repair by human telomerase reverse transcriptase over-expression in human cardiac mesenchymal stem cells
RNA-seq profiling of gene expression of human telomerase reverse transcriptase (hTERT)-expressing human cardiac mesenchymal stem cells.
ORGANISM(S): Homo sapiens 
2020-03-31 | GSE112297 | GEO
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