Human umbilical vein endothelial cells (huvecs)

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Tissue

Endothelial cell of umbilical vein (22)
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Vein endothelial cell (1)

Disease

Disease free (2)
AIDS-KS, HIV+, nodular (late) stage (1)
Non-diseased (1)
Colorectal Neoplasms (1)
Breast cancer (1)
Cardiovascular system disease (1)
Non-small cell lung carcinoma (1)
Pre-eclampsia (1)
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Mass Spectrometry (48)
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DiaPASEF (3)
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SWATH MS (3)
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Affinity purification coupled with mass spectrometry proteomics (2)
All-ion fragmentation (2)
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HDMSE (1)
Top-down proteomics (1)

Instrument Platform

NextSeq 500 (4)
Illumina HiSeq 2500 (3)
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Illumina HiSeq 2000 (3)
Q Exactive (3)
HiSeq X Ten (2)
NextSeq 550 (2)
Affymetrix GeneChip Scanner 3000 7G (1)
GenePix 4000A [Axon Instruments] (1)
NA (1)
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6550 iFunnel Q-TOF LC/MS (1)
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Agilent 5975T LTM GC/MSD (Agilent) (1)
Gas Chromatography MS - Positive (GC-MS (Positive)) (1)
Liquid Chromatography MS - negative (1)
Liquid Chromatography MS - negative - reverse-phase (1)
Liquid Chromatography MS - positive (1)
Liquid Chromatography MS - positive - reverse-phase (1)

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2013 (44)
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2014 (30)
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2012 (27)
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2015 (20)
2010 (20)
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2011 (18)
2017 (17)
2009 (17)
2018 (15)
2023 (13)
2008 (13)
2006 (8)
2005 (7)
2007 (6)
2004 (2)
2003 (1)

CHEBI ID

CHEBI:16015 (2)
CHEBI77168 (1)
CHEBI:131433 (1)
CHEBI:132999 (1)
CHEBI:133226 (1)
CHEBI:139369 (1)
CHEBI:142495 (1)
CHEBI:14336 (1)
CHEBI:144320 (1)
CHEBI:144322 (1)
CHEBI:144324 (1)
CHEBI:144325 (1)
CHEBI:144326 (1)
CHEBI:144327 (1)
CHEBI:144328 (1)
CHEBI:144329 (1)
CHEBI:144330 (1)
CHEBI:144331 (1)
CHEBI:144332 (1)
CHEBI:144333 (1)
CHEBI:144334 (1)
CHEBI:144335 (1)
CHEBI:144336 (1)
CHEBI:144337 (1)
CHEBI:144338 (1)
CHEBI:144339 (1)
CHEBI:144340 (1)
CHEBI:144341 (1)
CHEBI:144342 (1)
CHEBI:144343 (1)

Metabolite Name

(t-Butyldimethylsilyl)[3-methyl-3-(4-methyl-pent-3-enyl)-oxiran-2-yl]-methanone (1)
1 monostearin (1)
1,2,3-Thiadiazole, 5-methyl- (1)
1-(3-Methylbutyl)-2,3,4,6-tetramethylbenzene (1)
1-Heptanol, TMS derivative (1)
1-Hexene, 6-phenyl-4-(1-phenylethoxy)- (1)
1-Monomyristin, 2TMS derivative (1)
1-Monopalmitin, 2TMS derivative (1)
1-O-Tetradecylglycerol, 2TMS derivative (1)
1-O-hexadecylglycerol - bis-trimethylsilyl ether derivative (1)
1-Octadecanol, TMS derivative (1)
1-Phenylethanol, TMS derivative (1)
1-stearoyl-rac-glycerol (1)
13-Docosenoic acid, methyl ester (1)
18-Methyl-nonadecane-1,2-diol, isopropylidene derivative (1)
2(1H)-Pyrimidinone, 1-[2,3-bis-O-(trimethylsilyl)-.beta.-D-ribofuranosyl]-4-(trimethylsiloxy)-, 5'-[bis(trimethylsilyl) phosphate] (1)
2,3,4-Trihydroxybutyric acid tetrakis(trimethylsilyl) deriv., (, (R*,R*)-) (1)
2,3-Dihydroxypropyl icosanoate, 2TMS derivative (1)
2,5-Di-tert-butyl-4-((trimethylsilyl)oxy)phenol (1)
2,5-Furandicarboxylic acid, 2TMS derivative (1)
2-(Methylamino)ethanol, tert-butyldimethylsilyl ether (1)
2-Butenedioic acid, (E)-, 2TMS derivative (1)
2-Ketobutyric acid eo-tms (1)
2-Ketoglutaric acid, 2-(ethoxyimino)-, bis(trimethylsilyl) ester (1)
2-Monostearin, 2TMS derivative (1)
2-Oxo-6-phenyl-4-(4-hydroxyphenyl)-1,2-dihydropyrimidine (1)
2-Palmitoylglycerol, 2TMS derivative (1)
2-Pentenedioic acid, 3-methyl-, bis(tert-butyldimethylsilyl) ester (1)
2-Propanol, 1-bromo- (1)
3-.alpha.-Mannobiose, octakis(trimethylsilyl) ether (isomer 2) (1)

First Public Date

2025 (62)
2014 (60)
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2017 (24)
2019 (23)
2023 (20)
2021 (19)
2018 (15)
2016 (8)
2015 (7)
2013 (6)

Classification

fungi (1)

Study status

Not provided (1)

Study type

Transcription profiling by array (123)
RNA-seq of coding RNA (24)
ChIP-seq (14)
Unknown experiment type (7)
Other (5)
Cell line - High-throughput sequencing (2)
RNA-seq of total RNA (2)
RNA-seq of non coding RNA (2)
ChIP-chip by tiling array (1)
Human - High-throughput sequencing (1)
Cell line - One-color microarray (1)
Transcription profiling by tiling array (1)
RNAi profiling by array (1)
ChIP-chip by array (1)
Transcription profiling by RT-PCR (1)
MicroRNA profiling by high throughput sequencing (1)
DNA-seq (1)
Methylation profiling by high throughput sequencing (1)
Interventional (1)

Release Date

2022 (255)
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2020 (188)
2025 (184)
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2019 (143)
2017 (112)
2018 (94)
2016 (89)
2015 (72)
2014 (72)
2013 (62)
2012 (42)
2026 (34)
2011 (33)
2010 (32)
2009 (25)
2008 (20)
2007 (10)
2005 (9)
2003 (3)
2006 (2)
2004 (1)
2002 (1)

Lab affiliation

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt am Main, Germany (2)
Medical University of Vienna (2)
ULB - Faculty of PHARMACY RD3 - Pharmacognosy, Bioanalysis & Drug Discovery Unit & Analytical Platform of the Faculty of Pharmacy (2)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (2)
733 N. Broadway Miller Research Building room 527 Johns Hopkins University Baltimore, MD 21205 (1)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Angiogenesis & Metabolism Laboratory, Max Planck Institut for Heart and Lung Research, 61231 Bad Nauheim, Germany (1)
CRUK Beatson Institute (1)
Centre of Excellence in New Target Discovery (CENTD), Butantan Institute, Sao Paulo, Brazil. (1)
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid 28040, Spain. (1)
Chief, Section of Research and Tissue Engineering, Department of Plastic Surgery, University Medical Center Freiburg, Germany (1)
Chongqing Medical University (1)
Department of Biochemistry and Chemistry, Centre for Cardiovascular Biology and Disease Research, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Victoria 3086, Australia (1)
Department of Biological Chemistry Johns Hopkins University School of Medicine USA (1)
Department of Cardiology, Smidt Heart Institute and Proteomics and Metabolomics Core Facility (1)
Department of Neurology, Laboratory of Neuro‑Oncology, Clinical and Cancer Proteomics, Erasmus University Medical Center (1)
Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin (1)
Department of Obstetrics and Gynecology, University of Wisconsin-Madison, WI,USA. (1)
Department of Radiation Medicine Knight Cancer Institute and OHSU 2720 S Moody Avenue Portland, Oregon 97201, USA (1)
Discovery Proteomics Facility, Oxford (1)
EDyP (1)
Faculty of Pharmacy, University of Helsinki, Helsinki, Finland. (1)
Insitute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (1)
Institute of Cardiovascular Regeneration Centre of Molecular Medicine, Goethe University, Frankfurt am Main, Germany (1)
Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (1)
Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Pathology and Institute of Molecular Pathology,The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, The First Affiliated Hospital, Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China (1)
Keck MS & Proteomics Resource Yale School of Medicine (1)
Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, Alexandroupolis, 68100, Greece (1)
Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis (1)
MINT UMR Inserm 1066 CNRS 6021 IBS IRIS CHU 4 rue Larrey F-49933 ANGERS France (1)

Location

China (1)

Keyword

Capecitabine (1)
Efficacy (1)
Endostar (1)
Endostar protein (1)
Endostatins (1)
Oxaliplatin (1)

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The effect of the MYH9 in endothelial cells on metabolism

This document focuses on exploring the specific impact of MYH9 on the metabolic processes of vascular endothelial cells. To achieve this, a well-designed experimental approach was adopted: human umbilical vein endothelial cells (HUVECs) were subjected to different treatments using adenoviruses, i...

2026-03-05 | MTBLS12819 | MetaboLights

Long read proteogenomics to characterize protein isoform diversity in human umbilical vein endothelial cells (HUVECs)

Mass spectrometry-based proteomics sample preparation Harvested HUVECs, approximately 5 million cells each, were pelleted and frozen at -80C. The sample pellet was lysed according to the Filter Aided Sample Preparation (FASP) protocol.59 Lysis buffer used in the FASP was changed to 6% SDS, 150 mM DT...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2022-04-28 | MSV000089326 | MassIVE

Gene expression in human umbilical cord vein and artery endothelial cells under physiological chronic normoxia (3% O2, PCN) and standard culture normoxia (21% O2, SCN)

Endothelial cells, and many other types of cells too, physiologically reside in low O2 environments (~ 2-13% O2 or 15-60 mmHg pO2; [PCN]) relevantly to atmospheric O2 (~ 21% or 160 mmHg pO2 at sea level) in vivo. Such PCN is critical for endothelial functions. The majority of our current knowledge ...

ORGANISM(S): Homo sapiens

2013-08-30 | E-GEOD-49958 | biostudies-arrayexpress

Gene expression in human umbilical cord endothelial cells following FoxP1 knockdown

To search for genes regulated by the transcription factor Forkhead box Protein P1 (FoxP1) in endothelial cells, we transfected human umbilical cord endothelial cells (HUVECs) with a combination of three siRNA oligonucleotides directed against human FoxP1 . Human umbilical vein endothelial cells (HU...

ORGANISM(S): Homo sapiens

2013-11-12 | E-GEOD-32968 | biostudies-arrayexpress

RNA-seq of young and senescent human umbilical vein endothelial cells (HUVECs) under normal or high glucose conditions

Human endothelial cellular models are useful to disentangle the pathophysiological role of dysfunctional endothelium in the development of cardiovascular (CV) disease and organ damage in T2D. Here, we performed a RNAseq of human umbilical vein endothelial cells (HUVECs) undergoing replicative senesc...

ORGANISM(S): Homo sapiens

2024-04-08 | E-MTAB-13959 | biostudies-arrayexpress

Expression profiling in Human Umbilical Vein Endothelial Cells (HUVEC)

Whole transcriptome gene expression profiling of Normal -(HUVEC) Human Umbilical Vein Endothelial Cells The HUVEC gene expression results analyzed in this study are further described in Kustermann S. et al. (2014) A real-time impedance based screening assay for drug induced vascular leakage. A Nimbl...

ORGANISM(S): Homo sapiens

2014-01-07 | E-GEOD-52044 | biostudies-arrayexpress

Transcription profiling by array of human umbilical vein endothelial cells treated with valproic acid

Valproic acid (VPA) is a short-chain fatty acid used in the treatment of epilepsy and also considered to be an epigenetic modifier by functioning as a histone deacetylase (HDAC)-inhibitor. The aim of this study was to search for gene altered by VPA in human endothelial cells. Human umbilical vein en...

ORGANISM(S): Homo sapiens

2012-03-14 | E-GEOD-23909 | biostudies-arrayexpress

The genome expression profile of human umbilical vein endothelial cells (HUVECs) overexpressing miR-146a

Endothelial cells are critical for angiogenesis, and microRNAs plays important roles in this process. We investigated the regulatory role of microRNAs in endothelial cells of hepatocellular carcinoma (HCC) by examining the microRNA expression profile of human umbilical vein endothelial cells (HUVECs...

ORGANISM(S): Homo sapiens

2013-04-13 | E-GEOD-46022 | biostudies-arrayexpress

Transcription profiling of human umbilical vein endothelial cells after pulsed or continuous estradiol exposure

The experiment aims to investigate differences in the transcriptional response of human umbilical vein endothelial cells to estradiol treatment associated with the mode of administration. Human umbilical vein endothelial cells were treated for 5 days with a 1h pulse of 2.4 x 10-8 M 7β-estradiol (E2...

ORGANISM(S): Homo sapiens

2008-08-29 | E-MEXP-1227 | biostudies-arrayexpress

Microarray analysis of human umbilical vein endothelial cells (HUVECs) chronically irradiated with low dose-rate of ionizing radiation for one, three and six weeks.

To obtain more insight in the molecular effects of chronic low dose irradiation on endothelial cells, HUVEC were irradiated with low-dose rate irradiation (137Cs gamma source; 0, 1.4 and 4.1 mGy/h) for several weeks. At different time points (1, 3 and 6 weeks) cells were harvested for RNA extraction...

ORGANISM(S): Homo sapiens

2018-02-28 | E-MTAB-6521 | biostudies-arrayexpress

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