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TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells before and after vaccination with human papilloma virus-like particle
Human papilloma (HPV) virus-like particle (VLP) vaccines were recently licensed. Though neutralizing antibody titers are thought to be the main effectors of protection against infection, early predictors of long-term efficacy are not yet defined and a comprehensive understanding of innate and adapt...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-13587 | biostudies-arrayexpress
ProteomicsVirotrap: Abducting Protein Complexes from Mammalian Cells
Cell lysis is an inevitable step in classical affinity purification - mass spectrometry (AP-MS) strategies to map intracellular protein interactions. Cell homogenization implies a drastic change of the protein complex environment which strongly impedes comprehensive analysis. Complementary lysis con...
ORGANISM(S): Homo sapiens (Human) 
2016-04-27 | PXD000685 | Pride
Human vlp protein complex 
ProteomicsPlant-derived virus-like particle vaccines drive cross-presentation of influenza A hemagglutinin peptides by human monocyte-derived macrophages
A growing body of evidence supports the importance of T cell responses to protect against severe influenza, promote viral clearance and ensure long-term immunity. Plant-derived virus-like particle (VLP) vaccines bearing influenza hemagglutinin (HA) have been shown to elicit strong humoral and CD4+ T...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD010519 | Pride
Influenza Cell-mediated immunity Cross-presentation Major histocompatibility complex class i Human monocyte-derived macrophage High-resolution mass spectrometry Plant-derived vaccine Virus-like particle 
UnknownIn the activation of HPV-specific human B cells HPV-VLP vaccines mimic membrane-associated antigens.
Not available
S-EPMC11912367 | biostudies-literature
ProteomicsMHC I-restricted immunopeptidomics analysis of human monocyte-derived macrophages exposed to biological nanoparticles bearing influenza hemagglutinin
In this study, primary human monocyte-derived macrophages were exposed to plant-derived virus-like particles (VLPs) bearing influenza A hemagglutinin (HA) or soluble influenza HA, as control. Immunopurified MHC class I-associated peptides were analysed by nano-flow high pressure liquid chromatograph...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD010741 | Pride
Proteomics Human antigenic peptides Dopant-assisted electrospray ionisation (da-esi) Immunopeptidomics High-resolution mass spectrometry Class i major histocompatibility complex (mhc) Virus-like particle (vlp) Monocyte-derived macrophage (mdm) 
TranscriptomicsSingle-cell profiling (scRNA-seq with paired V(D)J) of the splenic response to VLP immunization in MZB KO versus wild-type mice
The precise role of Marginal Zone B (MZB) cells in shaping the adaptive immune response to virus-like particle (VLP) immunization remains incompletely defined. Here, we combined VLP immunization of wild-type and MZB-deficient mice with single-cell RNA sequencing (scRNA-seq) and paired TCR/BCR profil...
ORGANISM(S): Mus musculus 
2026-01-01 | E-MTAB-16268 | biostudies-arrayexpress
ProteomicsVirotrap: Abducting Protein Complexes from Mammalian Cells
Cell lysis is an inevitable step in classical affinity purification - mass spectrometry (AP-MS) strategies to map intracellular protein interactions. Cell homogenization implies a drastic change of the protein complex environment which strongly impedes comprehensive analysis. Complementary lysis con...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080790 | MassIVE
TranscriptomicsVpx of SIV modulates expression of innate immune target genes by inhibition of NF-κB activation
Background: In contrast to HIV-1, lentiviruses of the HIV-2/SIVmac/SIVsmm lineage are capable of efficient replication in myeloid cells due to the presence of their accessory protein Vpx. Vpx has been shown to induce degradation of the dNTP triphosphohydrolase SAMHD1, which is a cellular restriction...
ORGANISM(S): Homo sapiens 
2014-06-28 | GSE48542 | GEO
UnknownDevelopment of a Tag/Catcher-mediated capsid virus-like particle vaccine presenting the conserved Neisseria gonorrhoeae SliC antigen that blocks human lysozyme.
Not available
S-EPMC10715030 | biostudies-literature
UnknownDivergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production.
Not available
S-EPMC2704772 | biostudies-literature
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