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TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15616 | biostudies-arrayexpress
ProteomicsTumor-derived CDC37 inhibits antigen cross-presentation in dendritic cells and impairs anti-tumor immunity in breast cancer
Tumor mutational burden (TMB), usually representing high immunogenicity, could not always predict treatment response of immune checkpoint blockade (ICB). Here, we showed that defective antigen cross-presentation in type 1 conventional dendritic cells (cDC1) was responsible for lacking tumor-specific...
ORGANISM(S): Homo Sapiens 
2025-10-17 | PXD069576 |
ProteomicsProteomic analysis of regulated dendritic cell endosomes reveals dynamic adaptation to antigen uptake and cross-presentation
MHC class I cross-presentation involves final proteolytic peptide processing by the endosomal insulin-regulated aminopeptidase (IRAP). Reasoning that analysis of the IRAP proximal proteome may inform about dynamic remodeling of a key cross-presentation compartment during antigen uptake, we developed...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD067092 | Pride
Endosome Insulin-regulated aminopeptidase Proximity biotinylation Cross-presentation Dendritic cell 
GenomicsDNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
PRJNA1211014 | ENA
GenomicsAntigen cross-presentation at single-cell resolution
Antigen cross-presentation at single-cell resolution
PRJNA1237285 | ENA
TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose ...
ORGANISM(S): Mus musculus 
2009-06-19 | GSE15616 | GEO
TranscriptomicsImproved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
Attenuated poxviruses are safe and capable to express foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune respon...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-26239 | biostudies-arrayexpress
TranscriptomicsDNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
Innate immune receptors often induce activation of conventional dendritic cells (cDCs) and enhance antigen (cross-)presentation, favouring immune responses. DNGR-1 (CLEC9A), a receptor expressed by type 1 cDCs (cDC1s) and implicated in immune responses to viruses and cancer, recognises F-actin expos...
ORGANISM(S): Mus musculus 
2025-10-28 | GSE287030 | GEO
GenomicsMs4a7 expression in cDC1s determines cross-presentation and anti-tumor immunity
Ms4a7 expression in cDC1s determines cross-presentation and anti-tumor immunity
PRJNA1075093 | ENA
ProteomicsDirect quantification of viral epitope abundance reveals the importance of direct and cross-presentation in driving CTL responses during influenza infection
The magnitude of CD8+ T lymphocyte (CTL) responses to infection is a function of the available naïve T cell repertoire, combined with the context and duration of antigen presentation. Whilst T cell repertoires are relatively easily studied, the context and abundance of epitopes presented on infected...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-02 | PXD012728 | Pride
Srm Influenza Mrm Peptide Mhc 
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