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TranscriptomicsMicroarray analysis of the migrating human CD4+ T cell population from the spleen of humanized mice in response to treatment with Teplizumab or hIg
In order to identify genes expressed by cells that leave the spleen, the spleens were harvested from untreated reconstituted humanized mice (N=4) and a single cell suspension was prepared . The cultures were treated with either teplizumab (anti human CD3 hOKT3g1(Ala-Ala)) or hIg for 18 hrs in vitro...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-34163 | biostudies-arrayexpress
ProteomicsMolecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model
LC-MS/MS of Prss37 WT and KO mice male reproductive tract. Title: Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model Authors: Courtney Sutton1,2, Kaori Nozawa1,2, Katarzyna Kent1,2, Alexander Saltzman3, Mei Leng3, Sureshbabu Na...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-07 | MSV000091662 | MassIVE
TranscriptomicsEffects of pregnancy on hepatic gene expression in CYP2D6-humanized mice
Hepatic drug metabolism plays a key role in determining drug response and safety. Studies of drug metabolism generate valuable information about regulation of genes encoding drug-metabolizing enzymes and enzyme functions that are critical in developing dosing guideline. However, current knowledge is...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-50166 | biostudies-arrayexpress
GenomicsMDS in Humanized Mice
MDS in Humanized Mice
PRJNA517206 | ENA
GenomicsMDS in Humanized Mice
MDS in Humanized Mice
PRJNA517205 | ENA
GenomicsExosome derived from liver humanized mice
Exosome derived from liver humanized mice
PRJNA694142 | ENA
ProteomicsThe exhaled breath of humanized mice
This is GCxGC MS data from exhaled breath from humanized mice as well as germ-free controls. Raw files in CDF format (Figure S4D-F of associated publication)
ORGANISM(S): C57bl/6 Mice 
2025-08-15 | MSV000098837 | MassIVE
TranscriptomicsGene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are gener...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13588 | biostudies-arrayexpress
TranscriptomicsBulk RNA sequencing of cardiac tissue from MIK665-treated and placebo-treated humanized MCL-1 mice
This study comprises bulk RNA sequencing data generated from cardiac tissue of mice carrying a humanized MCL-1 receptor. Animals were treated with the selective MCL-1 inhibitor MIK665 or placebo. Cardiac tissue was collected at two experimental time points: during treatment (Day 14) and 7 days after...
ORGANISM(S): Mus musculus 
2026-08-28 | E-MTAB-16668 | biostudies-arrayexpress
TranscriptomicsHumanized Foxp2 Accelerates Making Transitions From Declarative to Procedural Learning
Purpose: Foxp2 is the first and for now the only gene connected to speech and language in humans. Two aminoacid substitutions took place in this protein during recent human evolution, after our split from the last common ancestor with chimpanzees, and are most likely to have undergone positive selec...
ORGANISM(S): Mus musculus 
2014-09-24 | E-GEOD-60659 | biostudies-arrayexpress
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