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TranscriptomicsSingle cell RNA-seq on human T cells isolated from humanized mice engraft with human PBMC and treated or not with PTCy post-transplantation
In order to assess the impact of PTCy on T cells in our humanized mouse GVHD model, we performed single cell RNA-sequencing on human T cells isolated from spleen of control and PTCy-treated mice on day 6 after hPBMC injection
ORGANISM(S): Homo sapiens 
2023-02-05 | E-MTAB-12188 | biostudies-arrayexpress
ProteomicsProteomics of Human and Mouse serum protein
Proteomics of human and mouse serum protein using nano-LC-MS/MS. In this study, humanized mice serum were included.
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2020-09-15 | PXD021477 | JPOST Repository
UnknownBoth T and B cells are indispensable for the development of a PBMC transfer-induced humanized mouse model for SSc.
Not available
S-EPMC9404611 | biostudies-literature
GenomicsRNA-seq of Tph and Tfh cells proliferated in the spleens of CD8T cells depleted PBMC-transferred humanized mice
RNA-seq of Tph and Tfh cells proliferated in the spleens of CD8T cells depleted PBMC-transferred humanized mice
PRJNA1332543 | ENA
UnknownTransfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice.
Not available
S-EPMC8261241 | biostudies-literature
GenomicsscRNA-seq of human CD45+ cells proliferated in the salivary grand or peripheral blood of CD8T cells depleted PBMC-transferred humanized mice
scRNA-seq of human CD45+ cells proliferated in the salivary grand or peripheral blood of CD8T cells depleted PBMC-transferred humanized mice
PRJNA1332536 | ENA
ProteomicsPharmacokinetic analysis of a novel human EGFRvIII:CD3 bispecific antibody in plasma and whole blood using a high-resolution targeted mass spectroscopy approach
Bi-specific single change antibody fragments (bi-scFv) represent an emerging class of biotherapeutics. We recently developed a fully human bi-scFv (EGFRvIII:CD3 bi-scFv) with the goal of redirecting CD3-expressiong T cells to recognize and destroy malignant, EGFR-expressing glioma. In mice, we showe...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD012472 | panorama
TranscriptomicsComparison of transcription profile of allogenic immune response generated in MLR and Humanzied mouse model
This experiment was carried out to demonstrate the efficacy of our novel humanized mouse model for identifying the best potential donor for the recipient. We performed a transcriptome analysis comparing the allogeneic immune response in MLR and the Hu-NSG-PBMC model. We identified several clinically...
ORGANISM(S): Mus musculus 
2021-04-04 | E-MTAB-10343 | biostudies-arrayexpress
UnknownA rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
Not available
S-EPMC7436391 | biostudies-literature
Genomics
RNA-Seq analysis of PBMC-humanized BT-474 tumor-bearing mice following DACH023-DXd treatment
PRJNA1483304 | ENA
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