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Humidifier disinfectant-associated lung injury (HDLI) is affected by long-term inhalational exposure to toxic polyhexamethylene guanidine (PHMG)-containing humidifier disinfectant (HD) and characterized by the rapid progression of respiratory failure with lung fibrosis and frequent air leak syndrome...
ORGANISM(S): Homo sapiens (Human) 
2025-09-12 | PXD026832 | Pride
Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury [rat]
Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury [human]
Humidifier disinfectant (HD)-associated lung injury (HDLI) not only associates with increased acute morbidity and mortality, but also affects long term lung function due to lung fibrosis. However, there have been no validated marker capable of detecting exposure to HDs or severity of HDLI. This stud...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD040122 | Pride
Inhalation of toxic chemicals, including recent e-cigarettes, often cause life-threatening lung injury. Although exposure to polyhexamethylene guanidine (PHMG)-containing humidifier disinfectant (HD) has been identified as a cause of fatal lung injury, the mechanism underlying HD-associated lung inj...
ORGANISM(S): Rattus norvegicus 
2021-07-06 | GSE179446 | GEO
Inhalation of toxic chemicals, including recent e-cigarettes, often cause life-threatening lung injury. Although exposure to polyhexamethylene guanidine (PHMG)-containing humidifier disinfectant (HD) has been identified as a cause of fatal lung injury, the mechanism underlying HD-associated lung inj...
ORGANISM(S): Homo sapiens 
2021-07-06 | GSE179445 | GEO
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