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GenomicsNatural variation of histone modification and its impact on gene expression in rat
Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. To begin to understand the impact of natural variation on histone methylation levels we generated and quantified large-scale ...
ORGANISM(S): Rattus norvegicus 
2012-05-30 | E-MTAB-1102 | biostudies-arrayexpress
GenomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites (MBD-seq)
Primary cells enter replicative senescence after a limited number of cell divisions. This process is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains unknown and may arise through drif...
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59960 | biostudies-arrayexpress
TranscriptomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites (RNA-seq)
Primary cells enter replicative senescence after a limited number of cell divisions. This process is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains unknown and may arise through drif...
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59966 | biostudies-arrayexpress
MetabolomicsCommon Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated ...
2019-08-19 | MTBLS678 | MetaboLights
UnknownPrognostic factors in nonsmall cell lung cancer: insights from the German CRISP registry.
Not available
S-EPMC9892864 | biostudies-literature
TranscriptomicsGene expression profiling in isogenic p53wt/p53ko Burkitt lymphoma cell line Seraphine after shRNA-mediated knock-down of p53 pathway members
We performed an shRNA-based RNAi interference screen targeting around 5,000 genes in eight Burkitt lymphoma cell lines. MDM4 and CDKN3 were essential genes in four p53 wild-type Burkitt lymphoma cell lines, but not in four p53 mutant cell lines. To investigate the effect of the gene knock-down on ce...
ORGANISM(S): Homo sapiens 
2019-08-01 | E-MTAB-7134 | biostudies-arrayexpress
UnknownEvaluation of the effectiveness of a nationwide precision medicine program for patients with advanced non-small cell lung cancer in Germany: a historical cohort analysis.
Not available
S-EPMC10687333 | biostudies-literature
Genomicsena-DATASET-MED-DUS-26-07-2016-11:14:36:814-193 - samples
26 cell lines derived from human Diffuse Large B Cell lymphomas (DLBCL) or Burkit Lymphomas (BL) were subjected to whole exome sequencing. Exome capture was carried out using the SeqCap EZ Exome Library 2.0 kit (Roche/Nimblegen) and 100 bp single-read sequencing was performed on a HiSeq2500 (Illumin...
EGAD00001002262 | EGA
GenomicsExome-sequencing of human B cell lymphoma cell lines
26 cell lines derived from human Diffuse Large B Cell lymphomas (DLBCL) or Burkit Lymphomas (BL) were subjected to whole exome sequencing. Exome capture was carried out using the SeqCap EZ Exome Library 2.0 kit (Roche/Nimblegen) and 100 bp single-read sequencing was performed on a HiSeq2500 (Illumin...
EGAS00001001463 | EGA
GenomicsSAHA-ZIM Data Access Committee
Data Access Committee EGAC00001000509
EGAC00001000509 | EGA
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