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TranscriptomicsExamining efficiency of enrichment of kidney pericyte-specific messages by TRAP (Translating Ribosome Affinity Purification)
The long term goal is to define the transcriptional changes that accompany pericyte-to-myofibroblast transition in fibrotic kidney disease. Medullary pericytes are identified by their expression of a eGFPL10a fusion protein whose expression is driven by a Col1a1 promoter. Pericyte-specific RNA is g...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-50439 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD14+ peripheral blood monocytes from subjects infected with H.drcreyi reveals host susceptibility to H. ducreyi infection is associated with unique transcript profiles in tissue and dendritic cells
Comparison of gene expression from subjects who resolved or formed pustules to H.ducreyi. In human inoculation experiments, the cutaneous immune response to Haemophilus ducreyi consists of serum, PMN, macrophages, T cells and myeloid DC. In reinfection experiments, some subjects form pustules twice...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5547 | biostudies-arrayexpress
ProteomicsIFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that limits viral pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human and mouse models, we demonstrate that IFITM3 promotes MyD88-dependent, TLR-mediated IL-6 production following exposure...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-28 | PXD035254 | Pride
Viral pathogenesis Ip-mass spec Silac 
UnknownCSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice.
Not available
S-EPMC2719924 | biostudies-literature
TranscriptomicsDevelopment of human cartilage circadian rhythm in a stem cell-chondrogenesis model
The circadian clock in murine articular cartilage is a critical temporal regulatory mechanism for tissue homeostasis and osteoarthritis. However, translation of these findings into humans has been hampered by the difficulty in obtaining circadian time series human cartilage tissues. As such, a suita...
ORGANISM(S): Homo sapiens 
2022-08-16 | E-MTAB-11758 | biostudies-arrayexpress
UnknownUnderestimation of Pearson's product moment correlation statistic.
Not available
S-EPMC6323088 | biostudies-literature
UnknownSequential Delivery of Live Attenuated Influenza Vaccine and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Ferret Model Can Reduce SARS-CoV-2 Shedding and Does Not Result in Enhanced Lung Pathology.
Not available
S-EPMC8689863 | biostudies-literature
UnknownicaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis.
Not available
S-EPMC135245 | biostudies-literature
UnknownSkills transfer to sinus surgery via a low-cost simulation-based curriculum.
Not available
S-EPMC5880692 | biostudies-literature
TranscriptomicsComplexity of Murine Cardiomyocyte miRNA Biogenesis, Sequence Variant Expression and Function
microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants. We subjected small RNA from murine HL-1 cardiomyocyte cells to next generation sequencing to investigate the r...
ORGANISM(S): Mus musculus 
2012-07-20 | E-GEOD-39531 | biostudies-arrayexpress
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