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TranscriptomicsIndividual-nucleotide resolution CLIP and high-throughput sequencing to map hnRNP L-RNA interactions in HeLa cells
Individual-nucleotide resolution UV-crosslinking and immunoprecipitation (iCLIP) combined with high-throughput sequencing was used to generate a transcriptome-wide binding map of hnRNP L. Supplementary file GSE37560_hnRNPL_crosslink_site.bed includes filtered crosslink sites of hnRNPL: combining da...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-37560 | biostudies-arrayexpress
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
GenomicsHdac6 regulates Tip60-p400 function in stem cells (sequencing)
The Tip60 (also known as Kat5) lysine acetyltransferase functions broadly as a transcriptional co-activator that acetylates histones. In contrast, Tip60 functions in embryonic stem cells (ESCs) both to silence genes that promote differentiation and to activate genes required for proliferation. The m...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-42209 | biostudies-arrayexpress
TranscriptomicshnRNP L-RNA in HeLa
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-37562 | biostudies-arrayexpress
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
ProteomicsA proteomic roadmap of ribosome heterogeneity during human embryonic stem cell differentiation
Recent findings suggest that the ribosome itself modulates gene expression. However, whether ribosomes change composition across cell types to control cell fate remains unknown. To determine the magnitude of ribosome heterogeneity and its functional contribution to cell fate specification, we measu...
ORGANISM(S): Homo sapiens (Human) 
2022-09-19 | PXD032904 | Pride
Differentiation Ribosome Tandem mass tags (tmt) Human embryonic stem cell 
UnknownImprovements in Upper Extremity Function Following Intensive Training Are Independent of Corticospinal Tract Organization in Children With Unilateral Spastic Cerebral Palsy: A Clinical Randomized Trial.
Not available
S-EPMC8127842 | biostudies-literature
UnknownInhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Not available
S-EPMC4023746 | biostudies-literature
UnknownA stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production.
Not available
S-EPMC9485161 | biostudies-literature
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