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ProteomicsSIRT6 phosphorylation - MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
Sirtuin 6 (SIRT6) is associated with longevity and was recently established as a tumor suppressor. Hence, identifying the molecular regulators of SIRT6 might enable its activation therapeutically in cancer patients. We found that SIRT6 was phosphorylated by the kinase AKT1 at Ser338, which induces i...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD001154 | Pride
Phosphorylation Sirt6 
ProteomicsTargeting WTX-P54nrb Phase Separation Sensitizes Chemotherapy in Gastric Cancer
To provide insights into any distinctions between the cellular functions of WTX-S and WTX-L, we defined their protein interaction networks by performing liquid chromatography–tandem MS of affinity-purified protein complexes.
ORGANISM(S): Homo Sapiens 
PXD057127 |
TranscriptomicsGene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice
Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivat...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-27478 | biostudies-arrayexpress
TranscriptomicsRegulation of Angiogenesis by EZH2
While VEGF-targeted therapies are showing promise in clinical studies, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homologue 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome. The increase in ...
ORGANISM(S): Homo sapiens 
2010-10-12 | E-GEOD-20381 | biostudies-arrayexpress
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