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ProteomicsThe sequence-specific peptide-binding activity of the protein sulfide isomerase AGR2 directs its’ stable binding to the oncogenic receptor EpCAM
AGR2 is an oncogenic endoplasmic reticulum (ER)-resident protein disulfide isomerase. AGR2 protein has a relatively unique property for a chaperone in that it can bind sequence-specifically to a peptide motif (TTIYY). A synthetic TTIYY-containing peptide column can be used to affinity-purify AGR2 f...
ORGANISM(S): Escherichia coli 
2018-01-22 | PXD005782 | Pride
Human Hdx Agr2 Protein-protein interaction Epcam Lc-ms/ms 
ProteomicsAn inter-subunit protein-protein interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin
Reptin forms multiple inter-subunit protein-protein interaction contacts. Rate-limiting motifs in ligand-dependent oligomer assembly are not defined. We set up a Reptin-self peptide scan assay to identify functional protein-protein interfaces that dominate in Reptin self assembly. The most dominant ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-23 | PXD008226 | Pride
Hdx mass spectrometry Oligomer assembly Protein-protein interaction Reptin 
ProteomicsHDX-MS implicates dynamic CD20 antigen binding to two discontinuous CDR regions in the NCD1.2 monoclonal antibody
A comparative canine-human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3 and light chain-7. However, the contribution...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2021-09-09 | PXD018550 | Pride
Human Comparative medicine Lymphoma Monoclonal antibody Hdx Adept Phage display Cd20 
ProteomicsHydrogen Deuterium Exchange Mass Spectrometry implicates dynamic CD20 antigen binding to two discontinuous CDR regions in the NCD1.2 monoclonal antibody
A comparative canine-human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3 and light chain-7. However, the contribution...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2021-09-09 | PXD018510 | Pride
Human Comparative medicine Lymphoma Monoclonal antibody Hdx Adept Phage display Cd20 Lc-ms/ms 
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