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MetabolomicsEMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion...

2021-10-15 | MTBLS1925 | MetaboLights
ProteomicsFat1 deletion promotes hybrid EMT state, tumor stemness, and metastasis
FAT1, a protocadherin, is among the most frequently mutated genes in human cancers1-5. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. In the present study we used different mouse cancer models including skin squ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD022268 | Pride
Stemness Fat1 Hybrid emt Metastasis 
ModelsSelvaggio2020 - Microenvironment control of hybrid Epithelial-Mesenchymal phenotypes
Epithelial to Mesenchymal Transition (EMT) has been associated with cancer cell heterogeneity, plasticity and metastasis. It has been the subject of several modeling effort. This logical model of the EMT cellular network aims to assess microenvironmental signals controlling cancer-associated phenoty...
2020-06-30 | MODEL2004040001 | BioModels
ModelsRegan2022 - Mechanosensitive EMT model
This file contains a 136-node modular Boolean network model of EMT triggered by biomechanical and growth signaling crosstalk, linked to a published network of epithelial contact inhibition, proliferation, and apoptosis (MODEL2006170001). This model reproduces the ability of the core EMT transcriptio...
2023-12-13 | MODEL2208050001 | BioModels
ModelsRegan2022 - Mechanosensitive EMT model with autocrine TGFbeta signaling
This model is an expansion of the Regan2022 - Mechanosensitive EMT model (MODEL2208050001); it includes a TGFβ signaling module and autocrine signaling in mesenchymal cells. The expanded 150-node (630 link) modular model undergoes EMT triggered by biomechanical and growth signaling crosstalk, or by ...
2023-12-13 | MODEL2208050002 | BioModels
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors
This SuperSeries is composed of the following subset Series: GSE32727: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human] GSE32904: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32905 | biostudies-arrayexpress
TranscriptomicsE-cadherin and EMT regulation by bHLH factors: a new role for the class I gene E2-2 (TCF4) and its comparison with E47.
Loss of expression of the cell-cell adhesion molecule E-cadherin is an essential event for epithelial-mesenchymal transition (EMT), a process that allows cell migration in the developing embryo and during tumour invasion. Transcriptional repression has emerged as the main mechanism responsible for E...
ORGANISM(S): Canis lupus familiaris 
2010-06-24 | E-GEOD-9145 | biostudies-arrayexpress
GenomicsA handful of hybrid EMT cells are characterized as the origin from lung adenocarcinoma
A handful of hybrid EMT cells are characterized as the origin from lung adenocarcinoma
PRJNA987618 | ENA
TranscriptomicsEMT is the dominant program in human colon cancer
This SuperSeries is composed of the following subset Series: GSE28567: EMT is the dominant program in human colon cancer (Affymetrix) GSE28709: EMT is the dominant program in human colon cancer (lung) GSE28722: EMT is the dominant program in human colon cancer (Agilent) Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-04-25 | E-GEOD-28814 | biostudies-arrayexpress
TranscriptomicsJag1-regulated hybrid-EMT state identifies a subset of CD9hi pancreatic tumour-initiating cells with enriched stemness
We previously identified a pancreatic ductal adenocarcinoma (PDAC) subpopulation capable of initiating PDAC and giving rise to PDAC heterogeneity, marked by the tetraspanin CD9. PDAC shows great cellular heterogeneity, with pronounced epithelial and mesenchymal cancer cell populations, and it has be...
ORGANISM(S): Mus musculus 
2026-04-18 | GSE245863 | GEO
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