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GenomicsHydroxychloroquine inhibits trained immunity
Hydroxychloroquine inhibits trained immunity
PRJNA670179 | ENA
ProteomicsQuantitative proteomics explores the potential targets and action mechanisms of hydroxychloroquine
Hydroxychloroquine (HCQ) is an autophagy inhibitor that has been used for the treatment of many diseases, such as malaria, rheumatoid arthritis, systemic lupus erythematosus, cancer, and so on. Despite the therapeutic advances in these diseases, the underlying mechanisms have not been well determine...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034196 | Pride
Quantitative proteomics Thermal proteome profiling Hydroxychloroquine Binding targets 
TranscriptomicsHydroxychloroquine inhibits trained immunity
We demonstrate that hydroxychloroquine inhibits trained immunity at the functional and epigenetic level and is accompanied by reduced expression of interferon-stimulated genes. Trained immunity comprises a functional adaptation induced by epigenetic reprogramming which facilitates the anti-viral inn...
ORGANISM(S): Homo sapiens 
2020-10-21 | GSE159678 | GEO
GenomicsRNA-seq of THP-1 cells stimulated with CpG-c and Hydroxychloroquine intervention
RNA-seq of THP-1 cells stimulated with CpG-c and Hydroxychloroquine intervention
PRJNA814494 | ENA
GenomicsTranscriptomics of vitiligo melanocytes after hydroxychloroquine treatment
Transcriptomics of vitiligo melanocytes after hydroxychloroquine treatment
PRJNA779610 | ENA
ProteomicsTargeting the mitochondrial recycling dysfunction in systemic lupus erythematosus (SLE) patients NK cells with Hydroxychloroquine (HCQ)
Objectives: Natural Killer (NK) cell dysfunction contributes to systemic lupus erythematosus (SLE) pathogenesis, but its underlying mechanisms remain poorly understood. This study investigates immunometabolic alterations in NK cells from SLE patients and explores therapeutic strategies for their res...
ORGANISM(S): Homo sapiens (Human) 
2026-01-14 | PXD059825 | Pride
Mitophagy Systemic lupus erythematosus (sle) Natural killer (nk) cells Mitochondrial dysfunction Hydroxychloroquine 
TranscriptomicsRNA-seq of THP-1 cells stimulated with CpG-c and Hydroxychloroquine intervention
Purpose: To investigate the inhibition of inflammatoty cytokines of Hydroxychloroquine to phagocytic THP-1 cells. Methods: we established a cell model of hemophagocytosis by simulating THP-1 cells with CpG-c for 24h in vitro to produce macrophages, and then coculture the cells with human RBCs. RNA s...
ORGANISM(S): Homo sapiens 
2022-07-01 | GSE198290 | GEO
UnknownHydroxychloroquine for the treatment of severe respiratory infection by COVID-19: A randomized controlled trial.
Not available
S-EPMC8478184 | biostudies-literature
ClinicalHydroxychloroquine + Vorinostat in Advanced Solid Tumors
This study is an open label non randomized study of hydroxychloroquine (HCQ) with histone deacetylase (HDAC) inhibitor Vorinostat in patients with advanced solid tumors to determine the maximum tolerated dose (MTD) and to evaluate the safety and antitumor activity of this drug combination.
2081555 | ecrin-mdr-crc
Transcriptomicssingle-cell RNA-seq of OVCAR3 and CCL218 cancer cells with evolved hydroxychloroquine resistance
OVCAR3 and CCL218 cells were passaged in the presence or absence of hydroxychloroquine. Drug pulse chases were used, with 48h of drug exposure followed by replacement of fresh media. Cells were allowed to grow to near confluence and then another drug pulse-chase was performed. After 15 hydroxychloro...
ORGANISM(S): Homo sapiens 
2024-03-18 | GSE245329 | GEO
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