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MetabolomicsGenetic mapping and molecular mechanism behind color variation in the Asian vine snake

BACKGROUND: Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of these conspicuous colors remains unresolved.

RESULTS: We investigate color morph-enriched Asian vine snakes...

2023-02-23 | MTBLS6927 | MetaboLights
ProteomicsProAlanase is an effective alternative to trypsin for proteomics applications and disulfide bond mapping
Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of digestion solution. In this study we characterized ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the ...
ORGANISM(S): Homo sapiens (Human) Loxodonta africana (African elephant) 
2020-10-19 | PXD019039 | Pride
Sequence coverage Proline-rich Disulfide mapping Low-ph Proteomics Phosphorylation De novo sequencing Disulfide bonds Proalanase 
ProteomicsData for Mass spectrometry analysis of collagen IV
Data for PHFR9 7S: 1. Raw file (6 files) 2. IDPicker files (1 file) 3. Database (1 file) Data for EHS mouse collagen IV: 1.Raw file ( 21 files) 2.IDPicker files (7 files) 3.Database (3 files) Mouse_data_CID_1=Trypsin;Mouse_data_CID_2=Glu C; Mouse_data_CID_3=Trypsin +Glu C; Mouse_data_ETD_1=Trypsin (...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2015-08-17 | MSV000079260 | MassIVE
UnknownIsolation and mass spectrometry based hydroxyproline mapping of type II collagen derived from Capra hircus ear cartilage.
Not available
S-EPMC6488623 | biostudies-literature
ProteomicsProAlanase is an effective alternative to trypsin for proteomics applications and disulfide bond mapping_part2
Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of digestion solution. In this study we characterized ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD021191 | Pride
Sequence coverage Proline-rich Disulfide mapping Low-ph Proteomics Phosphorylation De novo sequencing Disulfide bonds Histone ptms Proalanase Histone variants 
ProteomicsMass spectrometric analysis of Collagen alpha-1 (II) chain from Capra hircus
Expressional alterations and post translational modifications (PTM) of type II collagen can be major cause behind osteo and rheumatoid arthritis. PTM of type II collagen α1 chain (COL2A1) such as hydroxylation of proline (P), lysine and glycosylation of hydroxylysine can act as epitopes resulting CO...
ORGANISM(S): Capra hircus (Goat) 
2019-05-06 | PXD012911 | Pride
Capra hircus Collagen alpha-i (ii) Post translational modifications Hydroxyproline mapping 
ProteomicsMass spectrometric analysis of Collagen alpha-1 (II) chain from Capra hircus
Expressional alterations and post translational modifications (PTM) of type II collagen can be major cause behind osteo and rheumatoid arthritis. PTM of type II collagen α1 chain (COL2A1) such as hydroxylation of proline (P), lysine and glycosylation of hydroxylysine can act as epitopes resulting CO...
ORGANISM(S): Capra hircus (Goat) 
2019-05-06 | PXD012928 | Pride
Capra hircus Collagen alpha-i (ii) Post translational modifications Hydroxyproline mapping 
ProteomicsProteomic and degradomic signatures of extracellular matrix remodeling in calcific aortic valve
Calcific aortic valve disease (CAVD) is the most common valvular heart disease in older adults, but no medical therapy is currently able to halt or reverse its progression, partly because the molecular mechanisms of valve remodeling remain incompletely understood. Here, we aimed to dissect the extra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-29 | PXD073246 | Pride
Aortic valve stenosis Extracellular matrix remodeling proteomics Calcific aortic valve disease Collagen post-translational modifications 
UnknownStructural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
Not available
S-EPMC3188589 | biostudies-literature
ProteomicsProAlanase is an effective alternative to trypsin for proteomics applications and disulfide bond mapping_part3
Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of the digestion solution. In this study we characterize ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on t...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD021703 | Pride
Sequence coverage Proline-rich Low-ph Histones Proteomics Phosphorylation De novo sequencing Disulfide bonds Proalanase 
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