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ProteomicsArginine methylation during transcriptional arrest
The covalent attachment of methyl groups to the side-chain of arginine residues is known to play essential roles in regulation of transcription, protein function and RNA metabolism. The specific N-methylation of arginine residues is catalyzed by a small family of gene products known as protein argin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD000559 | Pride
Human cell culture 
TranscriptomicsThe C. elegans SNAP complex component SNPC-4 coats piRNA domains and globally affects piRNA abundance
Remarkably, tens of thousands of piwi-interacting RNAs (piRNAs) arise from a minimal number of discrete clustered regions in many organisms. However, it remains unclear if organization into these domains contributes to the highly coordinated, germline-specific expression of these small RNAs. Here, w...
ORGANISM(S): Caenorhabditis elegans 
2014-11-17 | E-GEOD-53412 | biostudies-arrayexpress
ProteomicsA human interactome in three quantitative dimensions organized by stoichiometries and abundances
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed glob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-06-17 | MSV000079835 | MassIVE
ProteomicsA human interactome in three quantitative dimensions organized by stoichiometries and abundances -- auxiliary dataset
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed glob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Saccharomyces Cerevisiae (ncbitaxon:4932) Mus Musculus (ncbitaxon:10090) 
2016-10-21 | MSV000080271 | MassIVE
UnknownAKT Inhibition in Solid Tumors With AKT1 Mutations.
Not available
S-EPMC5501365 | biostudies-literature
UnknownStructural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630.
Not available
S-EPMC4089486 | biostudies-literature
ProteomicsespL deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we show that EspL, a protein of 115 amino acids, is essential for mediating E...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-12-10 | PXD010929 | Pride
Mycobacterium Virulence Tuberculosis Espl 
UnknownSds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores
Not available
S-JCBD-201112112 | bioimages
TranscriptomicsGenome-scale RNAi profiling of cell division in human tissue culture cells
Cell division is a fundamental process for multicellula organisation. Here we report a genome-scale RNAi screen in HeLa cells designed to identify human genes important for cell division. We utilized a library of endoribonuclease-prepared siRNAs (esiRNAs) for gene-silencing and used DNA content an...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9176 | biostudies-arrayexpress
GenomicsChIP-Seq sequencing of novel interactors of H3K4me3, H3K36me3 and H3K9me3
This study describes the epigenetic profiling of the novel interactors of H3K4me3, H3K36me3 or H3K9me3. The interactors were ChIP-Seq profiled by their GFP tag in stably transfected HeLa (Kyoto) cells. The interactors include GATAD1, Sgf29, BAP18, TRRAP, PHF8, N-PAC and LRWD1 (including replicates),...
ORGANISM(S): Homo sapiens 
2010-09-17 | E-GEOD-20303 | biostudies-arrayexpress
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