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ProteomicsIn-bone digestion as a way to characterization of human maxillary and mandibular bone tissues
The project is based on in-bone digestion of proteins by trypsin directly in human maxillary and mandibular healthy and pathological bone samples without the prior reduction and alkylation of the disulfide bonds. The released peptides were then separated and identified by LC-MS/MS method.
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD026775 | Pride
In-bone digestion Mandibular bone Oral surgery Maxillary bone Tandem mass spectrometry 
ProteomicsDirect in-bone protein digestion with subsequent LC separation and trapped ion mobility MS detection of released peptides as an effective tool for the proteomic characterization of bone tissues
Common pathological changes in bone tissues like osteomas or exostoses remain not fully understood at the molecular level due to the difficulties in analyzing bone tissues in which they occur. Therefore, new rapid and powerful techniques are needed that could become routine tools for such analysis. ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD065656 | Pride
Skull base surgery Oral surgery In-bone peptide separation Osteomas Exostosis 
ProteomicsDirect tryptic cleavage in porcine alveolar bones tissue followed by LC-MS/MS
After a pre-incubation step with different solvents, specific digestion with trypsin was directly performed on porcine alveolar bone tissue. The released peptides were then analyzed using LC-MS/MS.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-06-12 | PXD018836 | Pride
Peptide mapping Alveolar bones Lc-ms/ms 
ProteomicsCharacterisation of vestibular schwannoma tissues using LC-MS/MS analysis
Vestibular schwannoma is the most common benign neoplasm of the cerebellopontine angle. Its first symptoms include hearing loss, tinnitus, and vestibular symptoms, followed by cerebellar and brainstem symptoms, along with palsy of the adjacent cranial nerves. However, the clinical picture has unpred...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045261 | Pride
Liquid chromatography In-sample protein digestion Tandem mass spectrometry Vestibular schwannomas Principal component analysis 
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