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TranscriptomicsTranscription profiling of human neutrophil and PBMC gene expression data from Jobs Syndrome individuals
Hyper IgE Recurrent Infection Syndrome (HIES or Job’s syndrome), is a rare disorder of immunity and connective tissue, typically manifest with boils, cyst-forming pneumonias, and extremely elevated serum IgE as well as retained primary dentition and bone abnormalities. Inheritance can be autosomal...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8507 | biostudies-arrayexpress
ProteomicsIdentification of immunodominant antigen among Brucella species (B. abortus and B. melitensis) using hyper immune serum from naturally infected hosts
In the present study, the whole cell protein extracts of B. abortus and B. melitensis were separated using SDS-PAGE and western blotting was carried out with the antiserum from naturally infected host animals (cow, buffalo, goat and sheep). The proteins bands that matched with western blot signals w...
ORGANISM(S): Brucella abortus Brucella melitensis Brucella 
2014-12-01 | PXD001270 | Pride
Hyper immune serum Immunodominat proteins Brucella Maldi tof ms Western blotting 
TranscriptomicsmiRNA expression profiles in the serum of cats with hypertrophic cardiomyopathy compared to healthy cats
MicroRNAs negatively regulate gene expression and may serve as biomarkers for human cardiomyopathy. In the domestic cat, hypertrophic cardiomyopathy (HCM) represents the most common primary cardiomyopathy. In humans, the etiology of HCM is linked to mutations in genes of contractile muscle proteins,...
ORGANISM(S): Felis catus 
2015-07-22 | E-GEOD-49427 | biostudies-arrayexpress
TranscriptomicsHigh titers and low fucosylation of early anti-SARS-CoV-2 IgG promote hyper-inflammation by anti-inflammatory macrophages (MIL10)
Patients diagnosed with coronavirus disease 2019 (COVID-19) mostly become critically ill around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early phase severe acu...
ORGANISM(S): Homo sapiens 
2021-04-30 | E-MTAB-10431 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of peripheral blood from patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls
This study investigates the molecular mechanisms of hypertrophic cardiomyopathy (HCM), a common genetic heart disease where the link between cardiac remodeling and immune response is not fully understood. We aimed to identify novel diagnostic biomarkers and explore transcriptomic alterations in peri...
ORGANISM(S): Homo sapiens 
2025-11-17 | E-MTAB-15843 | biostudies-arrayexpress
UnknownFunctional Defects in Type 3 Innate Lymphoid Cells and Classical Monocytes in a Patient with Hyper-IgE Syndrome.
Not available
S-EPMC5662784 | biostudies-literature
TranscriptomicsResponse of several cell lines originated from liver, skin and colon to stimulation by IFNg, hyper-IL6, IL27 and OSM, investigated at microRNA level
In this study 6 cell lines originated from liver, skin and colon tumours as well as 3 non-tumour cell lines from the same organs were profiled with and without stimulation by 4 cytokines: IFNg, hyper-IL6, IL27 and OSM. The main objective was investigation of downstream effects of the stimulation if ...
ORGANISM(S): Homo sapiens 
2021-04-07 | E-MTAB-9118 | biostudies-arrayexpress
TranscriptomicsResponse of several cell lines originated from liver, skin and colon to stimulation by IFNg, hyper-IL6, IL27 and OSM, investigated at mRNA level
In this study 6 cell lines originated from liver, skin and colon tumours as well as 3 non-tumour cell lines from the same organs were profiled with and without stimulation by 4 cytokines: IFNg, hyper-IL6, IL27 and OSM. The main objective was investigation of downstream effects of the stimulation if ...
ORGANISM(S): Homo sapiens 
2018-10-01 | E-MTAB-6080 | biostudies-arrayexpress
ProteomicsIL-36 is a hallmark of Netherton syndrome with type I IFN, Th2 and Th9 responses distinguishing its dual clinical manifestations
Netherton syndrome (NS) is a rare recessive skin disorder caused by loss-of-function mutations in the gene SPINK5 encoding the protease inhibitor LEKTI. NS patients suffer from a severe skin barrier defect, display inflammatory skin lesions and superficial scaling with atopic manifestations. They ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-18 | MSV000086716 | MassIVE
ProteomicsExploration on survived mice after sepsis and proteomic analy-sis on LPS-activated macrophages supports the regulation of sepsis hyper-inflammation by intravenous immunoglobulin
Because the immune regulation in survivor after sepsis (an immune dysregulation from severe infection) might be applied for treatment, survivors and moribund mice after cecal liga-tion and puncture (CLP) and in vitro experiments on macrophages were explored. Most of the parameters in survivors (5-da...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD027471 | Pride
Sepsis  clp  macrophages  proteomic analysis  ivig 
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