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ProteomicsHyperLOPIT and temporal proteomic profiling of the response to lipopolysaccharide in the THP-1 human leukaemia cell line
The hyperLOPIT proteomics platform combines mass-spectrometry with state-of-the-art machine learning for simultaneous “mapping” of the steady-state subcellular location of thousands of proteins. Here, we use a synergistic approach and combine global proteome analysis with hyperLOPIT in a fully Bayes...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023509 | Pride
Hyperlopit Thp-1 cells Immune response Lc-ms/ms 
GenomicsIn vivo CRISPR screens for Toxoplasma hyperLOPIT-unassigened proteins_2
In vivo CRISPR screens for Toxoplasma hyperLOPIT-unassigened proteins_2
PRJNA1067615 | ENA
GenomicsIn vivo CRISPR screens for Toxoplasma hyperLOPIT-unassigened proteins_1
In vivo CRISPR screens for Toxoplasma hyperLOPIT-unassigened proteins_1
PRJNA1067616 | ENA
OtherIn vivo CRISPR screens for Toxoplasma hyperLOPIT-unassigened proteins_2
We performed in vivo CRISPR screens of Toxoplasma targeting hyperLOPIT-unassigened genes during mouse infection.
ORGANISM(S): Toxoplasma gondii RH 
2024-06-30 | GSE253885 | GEO
OtherIn vivo CRISPR screens for Toxoplasma hyperLOPIT-unassigened proteins_1
We performed in vivo CRISPR screens of Toxoplasma targeting genes with hyperLOPIT-unassigened subcellular localisation during mouse infection.
ORGANISM(S): Toxoplasma gondii RH 
2024-06-30 | GSE253884 | GEO
UnknownCRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma.
Not available
S-EPMC11389413 | biostudies-literature
ProteomicsSpatial proteome map of Cryptosporidium parvum sporozoite
Cryptosporidium is a leading cause of diarrheal disease in children and an important contributor to early childhood mortality. The parasite invades intestinal epithelial cells and remodels them extensively including building an elaborate interface structure. How this occurs at the molecular level is...
ORGANISM(S): Cryptosporidium parvum virus 1 Cryptosporidium parvum Iowa II 
2023-03-30 | PXD038366 | Pride
Cryptosporidium Small granules Secretion Sps-ms3 Rhoptry Organelle Tmt Apicomplexa Hyperlopit Spatial proteome Dense granules Effectors Microneme 
ProteomicsHigh-resolution spatial proteome map of Toxoplasma gondii extracellular tachyzoite
Apicomplexans, such as malaria-causing Plasmodium species, Toxoplasma, and Cryptosporidium, are parasitic protists that invade cells of virtually every animal, including humans. Despite the great burden on human healthcare and global economy, and the role in the environment, our understanding of the...
ORGANISM(S): Toxoplasma gondii 
2020-10-14 | PXD015269 | Pride
Machine learning Sub-cellular Localization Sps-ms3 Parasite Localisation Compartments Toxoplasma gondii Apicomplexa Organelles Tmt10plex Subcellular Protist Spatial 
ProteomicsHigh-resolution spatial proteomics of Plasmodium falciparum schizonts using hyperLOPIT and TMT-based mass spectrometry
This dataset contains a hyperLOPIT spatial proteomics experiment performed on Plasmodium falciparum to determine the subcellular localization of parasite proteins. Schizont-stage parasites were fractionated by density gradient centrifugation, and collected fractions were labelled with tandem mass ta...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2026-06-01 | PXD070842 | Pride
ProteomicsLOPIT-DC subcellular map of U-2 OS cells
Generation of a high-resolution subcellular localisation map for the proteome of the human cancer cell line U-2 OS, using the newly developed LOPIT-DC method. Comparison of the results generated using LOPIT-DC with data generated using the well-established hyperLOPIT method and data mining regarding...
ORGANISM(S): Homo sapiens (Human) 
2019-01-23 | PXD011254 | Pride
Lopit-dc Hyperlopit Cancer subcellular map Spatial proteomics 
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