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ProteomicsPalmitoylation couples insulin hypersecretion with β-cell failure in diabetes
Hyperinsulinemia often precedes type 2 diabetes but its role in disease progression is unknown. Palmitoylation, a protein modification implicated in regulated exocytosis, is reversed by acyl-protein thioesterase 1 (APT1). We found altered APT1 biology in pancreatic islets from humans with type 2 dia...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-05 | PXD038554 | Pride
Proteomics Palmitoylation Pancreatic islet Insulin Diabetes 
GenomicsBlockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice
Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice
PRJNA1064932 | ENA
UnknownPalmitoylation couples insulin hypersecretion with β cell failure in diabetes.
Not available
S-EPMC9908855 | biostudies-literature
GenomicsApplication of text mining to build AOP-based mucus hypersecretion genesets and validation with in vitro and clinical samples
Application of text mining to build AOP-based mucus hypersecretion genesets and validation with in vitro and clinical samples
PRJNA595912 | ENA
UnknownRole of computed tomography in predicting adrenal adenomas with cortisol hypersecretion.
Not available
S-EPMC10461282 | biostudies-literature
TranscriptomicsGene Expression Signature in Adipose Tissue of Acromegaly Patients
OBJECTIVE: Acromegaly is a rare endocrine disorder with excess growth hormone (GH) production. This disorder has important metabolic effects in insulin resistance and lipolysis. The objective of this study was to explore transcriptional changes induced by GH in adipose tissue. METHODS: The patients ...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-57803 | biostudies-arrayexpress
TranscriptomicsApplication of text mining to build AOP-based mucus hypersecretion genesets and validation with in vitro and clinical samples
Purpose: Build genesets using text mining and validate the geneset with data from public repository and a dataset generated in house using in vitro models and RNA-seq Methods: Mucus hypersecretion and mucociliary dysfucntion adverse outcome pathways (AOPs) genesets were build using the text mining m...
ORGANISM(S): Homo sapiens 
2020-04-30 | GSE142100 | GEO
GenomicsBeta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion
Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion
PRJNA669991 | ENA
UnknownVDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells.
Not available
S-EPMC12266945 | biostudies-literature
Unknownβ2-Adrenoceptor involved in smoking-induced airway mucus hypersecretion through β-arrestin-dependent signaling.
Not available
S-EPMC4048185 | biostudies-literature
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