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GenomicsAdipose microenvironment promotes hypersialylation of ovarian cancer cells
Adipose microenvironment promotes hypersialylation of ovarian cancer cells
PRJNA1123758 | ENA
UnknownC-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.
Not available
S-EPMC10507237 | biostudies-literature
UnknownTargeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell-mediated tumor responses.
Not available
S-EPMC9198929 | biostudies-literature
TranscriptomicsAdipose microenvironment promotes hypersialylation of ovarian cancer cells
Sialylation, the addition of negatively charged sialic acid sugars to terminal ends of glycans, is upregulated in most cancers. Hypersialylation supports multiple pro-tumor mechanisms such as enhanced migration and invasion, resistance to apoptosis and immune evasion. A current gap in knowledge is t...
ORGANISM(S): Homo sapiens 
2024-08-14 | GSE269831 | GEO
UnknownResistance to complement activation, cell membrane hypersialylation and relapses in chronic lymphocytic leukemia patients treated with rituximab and chemotherapy.
Not available
S-EPMC6114972 | biostudies-literature
UnknownCD21<sup>low</sup> B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation.
Not available
S-EPMC11861550 | biostudies-literature
UnknownAdipose microenvironment promotes hypersialylation of ovarian cancer cells.
Not available
S-EPMC11299042 | biostudies-literature
TranscriptomicsTargeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade
Immune checkpoint blockade (ICB) has significantly improved the prognosis of cancer patients, but the majority experience limited benefit, evidencing the need for new therapeutic approaches. Upregulation of sialic acid-containing glycans, termed hypersialylation, is a common feature of cancer-associ...
ORGANISM(S): Mus musculus 
2022-11-24 | GSE208133 | GEO
UnknownInsights into the role of sialylation in cancer progression and metastasis.
Not available
S-EPMC7782833 | biostudies-literature
UnknownNeuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation.
Not available
S-EPMC12352893 | biostudies-literature
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