Sort   by:  
 Page size 
TranscriptomicsInteraction between diabetes and hypertension in a rat model of diabetic nephropathy
Fisher male Cyp1a1mRen2 rats were allocated into four groups of four biological replicates each: control; streptozotocin-induced diabetes alone; indole-3-carbinol induced hypertension alone; combined induced diabetes and hypertension.
Kidneys were harvested for microarray analysis.analysis.
ORGANISM(S): Rattus norvegicus 
2011-12-31 | E-MEXP-3165 | biostudies-arrayexpress
ProteomicsDeacetylation of Septin4 by NAD-dependent deacetylase SIRT2 mitigates damaging effects of hypertensive nephropathy
RATIONALE: Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating podocyte apoptosis has clinical significance for the treatment of hypertensive nephropathy, an effective therapeutic target has not yet been identified. The ...
ORGANISM(S): Mus Musculus 
2022-12-05 | PXD038538 |
ProteomicsGlomerular proteomic profiling of kidney biopsies with hypertensive nephropathy reveals a signature of disease progression
Background and Objective: Hypertensive nephropathy (HN) requires a kidney biopsy as gold-standard for its diagnosis but histological findings are not entirely specific and lack specific prognostic markers. We aimed at defining prognostic candidate markers based on glomerular protein signatures. Meth...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD026709 | Pride
Human Microdissection Hypertensive nephropathy Kidney Glomerulus Proteomics 
TranscriptomicsDiabetes and hypertension then reversal in a rat model of diabetic nephropathy
Fisher male Cyp1a1mRen2 rats were allocated into three groups of four or eight biological replicates each: control; combined induced diabetes and hypertension; removal of combined treatments. Kidneys were harvested for gene expression microarray analysis on Affymetrix GeneChip Rat Genome 230 2.0 Gen...
ORGANISM(S): Rattus norvegicus 
2013-04-10 | E-MEXP-3739 | biostudies-arrayexpress
GenomicsSingle-cell RNA transcriptomics of hypertensive nephropathy patients
Single-cell RNA transcriptomics of hypertensive nephropathy patients
PRJNA868215 | ENA
GenomicsRNA-Seq analysis of kidney transcriptome profiles in young spontaneously hypertensive rats and revealing the protective effects and potential therapeutic targets of SGLT2 inhibitors in early hypertensive nephropathy
RNA-Seq analysis of kidney transcriptome profiles in young spontaneously hypertensive rats and revealing the protective effects and potential therapeutic targets of SGLT2 inhibitors in early hypertensive nephropathy
PRJNA854094 | ENA
TranscriptomicsRNA-Seq analysis of kidney transcriptome profiles in young spontaneously hypertensive rats and revealing the protective effects and potential therapeutic targets of SGLT2 inhibitors in early hypertensive nephropathy
Hypertensive nephropathy is a common complication of hypertension that places a heavy burden on society. SGLT2 inhibitors are a new class of hypoglycemic agents that have been shown to have specific protective effects on the kidneys. This study aimed to investigate the early changes in renal transcr...
ORGANISM(S): Rattus norvegicus 
2024-06-30 | GSE207191 | GEO
TranscriptomicsSingle-cell RNA transcriptomics of hypertensive nephropathy patients
Hypertensive nephropathy (HTN) emerges as one of the leading causes of end-stage renal disease, yet the precise mechanisms and cell-specific gene expression changes are still unknown. This study used single-cell RNA sequencing (scRNA-seq) to explore novel molecular mechanisms and hub gene targets fo...
ORGANISM(S): Homo sapiens 
2023-08-31 | GSE210898 | GEO
UnknownMechanism of herbal medicine on hypertensive nephropathy (Review).
Not available
S-EPMC7893801 | biostudies-literature
UnknownMechanism of ferroptosis in hypertensive nephropathy.
Not available
S-EPMC9177265 | biostudies-literature
Sort   by:  
 Page size