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TranscriptomicsTranscription profiling of two transgenic models familial hypertrophic cardiomyopathy mice vs wild type and non transgenic controls using pooled and non pooled heart extracts to identify differences in gene expression in FHC
Familial hypertrophic cardiomyopathy (FHC) is a disease characterized by ventricular hypertrophy, fibrosis, and aberrant systolic and/or diastolic function. We previously developed two transgenic mouse models that carry FHC associated mutations in alpha-tropomyosin (TM): FHC alpha-TM175 mice show pa...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4678 | biostudies-arrayexpress
ProteomicsMouse model for hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes that code for the structural proteins of the sarcomere, is the most common inherited heart disease. HCM is associated with progressive myocardial hypertrophy and fibrosis, ventricular dysfunction, and arrhythmias. Dise...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-20 | PXD038911 | Pride
Mouse Proteomics Heart Hypertrophic cardiomyopathy Dda 
TranscriptomicsTranscriptional effects of CTGF inhibition in a transgenic mouse model of dilated cardiomyopathy
Cardiac structural changes associated with dilated cardiomyopathy (DCM) include cardiomyocyte hypertrophy and myocardial fibrosis. Connective Tissue Growth Factor (CTGF) has been associated with tissue remodeling and is highly expressed in failing hearts. To test if inhibition of CTGF would alter ...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-68857 | biostudies-arrayexpress
ProteomicsTargeting inflammation and metabolism in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes that code for the structural proteins of the sarcomere, is the most common inherited heart disease. HCM is associated with progressive myocardial hypertrophy and fibrosis, ventricular dysfunction, and arrhythmias. Dise...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD067090 | Pride
Pioglitazone Hypertrophic cardiomyopathy Myocardial hypertrophy 
TranscriptomicsMicroarray Analysis of a Familial Hypertrophic Cardiomyopathy Mouse Model Rescued by a Phospholamban Knockout
Familial hypertrophic cardiomyopathy (FHC) is a disease characterized by ventricular hypertrophy, fibrosis, and aberrant systolic and/or diastolic function. Our laboratories have previously developed 2 mouse models that affect cardiac performance. One transgenic mouse model encodes an FHC-associated...
ORGANISM(S): Mus musculus 
2012-12-13 | E-GEOD-42892 | biostudies-arrayexpress
ProteomicsTargeting inflammation and metabolism in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes that code for the structural proteins of the sarcomere, is the most common inherited heart disease. HCM is associated with progressive myocardial hypertrophy and fibrosis, ventricular dysfunction, and arrhythmias. Dise...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD067096 | Pride
Pioglitazone Hypertrophic cardiomyopathy Myocardial hypertrophy 
ProteomicsA Proteomic Analysis of the Myocardium in Hypertrophic Obstructive Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is characterised by a complex phenotype that is only partly explained by the biological effects of individual genetic variants. The aim of this study was to use proteomic analysis of myocardial tissue to explore thepostgenomic phenotype.
ORGANISM(S): Homo sapiens (Human) 
2019-08-14 | PXD011994 | Pride
Hypertrophic cardiomyopathy fibrosis proteomics 
TranscriptomicsGene expression profiling of a mouse model of dilated cardiomyopathy
Analysis of the effects of aging on the development of dilated cardiomyopathy by characterizing both changes in ejection fraction (EF) and gene expression profile in 3 groups of male mice: Control (Cont or WT, n=11) and transgenic (Tg or KO) mice with either high EF (KO-H or Tg-H, n=7) or low EF (K...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-16909 | biostudies-arrayexpress
ProteomicsInterleukin-8 mediated cellular crosstalk drives hypertrophic cardiomyopathy in LZTR1 2 deficiency
LZTR1 deficiency causes Noonan syndrome (NS) and is associated with the manifestation of severe and early-onset hypertrophic cardiomyopathy (HCM). Although paracrine communication is thought to play a critical role in cardiac pathology, little is known about the underlying pathomechanism leading to ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD053691 | Pride
Lztr1 Ipscs Noonan syndrome Cxcr1/2 51 inhibition Disease modeling Cardiac fibrosis Hypertrophic cardiomyopathy Interleukin-8 Tissue engineering 
UnknownCardiovascular Magnetic Resonance Imaging of Myocardial Interstitial Expansion in Hypertrophic Cardiomyopathy.
Not available
S-EPMC3973947 | biostudies-literature
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