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ProteomicsInterleukin-8 mediated cellular crosstalk drives hypertrophic cardiomyopathy in LZTR1 2 deficiency
LZTR1 deficiency causes Noonan syndrome (NS) and is associated with the manifestation of severe and early-onset hypertrophic cardiomyopathy (HCM). Although paracrine communication is thought to play a critical role in cardiac pathology, little is known about the underlying pathomechanism leading to ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD053691 | Pride
Lztr1 Ipscs Noonan syndrome Cxcr1/2 51 inhibition Disease modeling Cardiac fibrosis Hypertrophic cardiomyopathy Interleukin-8 Tissue engineering 
TranscriptomicsFilarial nematode AsnRS interacts with interleukin 8 receptors in iDCs but causes different gene expression patterns compared to iDCs stimulated by interleukin 8.
Nematode derived substances are known to down regulate host immune responses in order to survive in the human host. Brugia malayi is a parasitic nematode responsible for long lasting and disabling infection known as lymphatic filariasis in humans. The therapeutic benefit of a controlled parasitic ...
ORGANISM(S): Homo sapiens 
2012-12-08 | E-GEOD-39999 | biostudies-arrayexpress
Genomicshuman oral metagenome
The human oral microbiota and interleukin 8 levels
PRJNA320703 | ENA
UnknownGiardia duodenalis cathepsin B proteases degrade intestinal epithelial interleukin-8 and attenuate interleukin-8-induced neutrophil chemotaxis.
Not available
S-EPMC4097641 | biostudies-literature
UnknownCharacterization of buffalo interleukin 8 (IL-8) and its expression in endometritis.
Not available
S-EPMC6299738 | biostudies-literature
UnknownCombined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells.
Not available
S-EPMC6738883 | biostudies-literature
ProteomicsIL-36 is a hallmark of Netherton syndrome with type I IFN, Th2 and Th9 responses distinguishing its dual clinical manifestations
Netherton syndrome (NS) is a rare recessive skin disorder caused by loss-of-function mutations in the gene SPINK5 encoding the protease inhibitor LEKTI. NS patients suffer from a severe skin barrier defect, display inflammatory skin lesions and superficial scaling with atopic manifestations. They ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-18 | MSV000086716 | MassIVE
UnknownHaptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia.
Not available
S-EPMC4685105 | biostudies-literature
UnknownIncreased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer.
Not available
S-EPMC3139587 | biostudies-literature
TranscriptomicsMadin-Darby Canine Kidney (MDCK) cells grown in 2-dimensional and 3-dimensional type I collagen culture.
In order to gain insight into epithelial morphogenesis and the influence of culture geometry on gene expression patterns, Madin Darby Canine Kidney (MDCK) epithelial cells where grown in 2-dimensional (2D) culture or 3-dimensional (3D) culture . MDCK cells cultured in 2D were plated atop a pre-soli...
ORGANISM(S): Canis lupus familiaris 
2013-06-03 | E-GEOD-28381 | biostudies-arrayexpress
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