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ProteomicsMouse model for hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes that code for the structural proteins of the sarcomere, is the most common inherited heart disease. HCM is associated with progressive myocardial hypertrophy and fibrosis, ventricular dysfunction, and arrhythmias. Dise...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-20 | PXD038911 | Pride
Mouse Proteomics Heart Hypertrophic cardiomyopathy Dda 
ProteomicsA Proteomic Analysis of the Myocardium in Hypertrophic Obstructive Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is characterised by a complex phenotype that is only partly explained by the biological effects of individual genetic variants. The aim of this study was to use proteomic analysis of myocardial tissue to explore thepostgenomic phenotype.
ORGANISM(S): Homo sapiens (Human) 
2019-08-14 | PXD011994 | Pride
Hypertrophic cardiomyopathy fibrosis proteomics 
ProteomicsTargeting inflammation and metabolism in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes that code for the structural proteins of the sarcomere, is the most common inherited heart disease. HCM is associated with progressive myocardial hypertrophy and fibrosis, ventricular dysfunction, and arrhythmias. Dise...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD067090 | Pride
Pioglitazone Hypertrophic cardiomyopathy Myocardial hypertrophy 
ProteomicsTargeting inflammation and metabolism in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes that code for the structural proteins of the sarcomere, is the most common inherited heart disease. HCM is associated with progressive myocardial hypertrophy and fibrosis, ventricular dysfunction, and arrhythmias. Dise...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD067096 | Pride
Pioglitazone Hypertrophic cardiomyopathy Myocardial hypertrophy 
ProteomicsInterleukin-8 mediated cellular crosstalk drives hypertrophic cardiomyopathy in LZTR1 2 deficiency
LZTR1 deficiency causes Noonan syndrome (NS) and is associated with the manifestation of severe and early-onset hypertrophic cardiomyopathy (HCM). Although paracrine communication is thought to play a critical role in cardiac pathology, little is known about the underlying pathomechanism leading to ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD053691 | Pride
Lztr1 Ipscs Noonan syndrome Cxcr1/2 51 inhibition Disease modeling Cardiac fibrosis Hypertrophic cardiomyopathy Interleukin-8 Tissue engineering 
GenomicsContribution of hypoxia-inducible 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy
Contribution of hypoxia-inducible 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy
PRJNA1108190 | ENA
ProteomicsInhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder, characterized by cardiomyocyte hypertrophy, cardiomyocyte disarray and fibrosis, which has a prevalence of ~1:200-500 and predisposes individuals to sudden death and heart failure. The mechanisms through which d...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD042904 | Pride
Proteomics Micro rna Cardiac fibroblast Secretome 
UnknownComprehensive Proteomics Profiling Reveals Circulating Biomarkers of Hypertrophic Cardiomyopathy.
Not available
S-EPMC8292216 | biostudies-literature
UnknownContribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy.
Not available
S-EPMC11739497 | biostudies-literature
TranscriptomicsContribution of hypoxia-inducible 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy
Aims: Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. HCM is associated with progressive myocardial hypertrophy, fibrosis, ventricular dysfunction, and arrhythmias. Hypoxia togeth...
ORGANISM(S): Mus musculus 
2025-01-22 | GSE266649 | GEO
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