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ORGANISM(S): Rattus norvegicus 
Repeated exposures to insulin-induced hypoglycemia in diabetic patients progressively impair the counter-regulatory response (CRR) that restores normoglycemia. This defect is characterized by reduced secretion of glucagon and other counter-regulatory hormones. Evidence indicates that glucose respons...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-13 | PXD040183 | Pride
In order to gain further insight into the molecular mechanism(s) mediating the blunted epinephrine responses following recurrent hypoglycemia we utilized global gene expression profiling approach. Our results indicate the association between defective counterregulation (impaired epinephrine release)...
ORGANISM(S): Rattus norvegicus 
We report the results of AcH3K9 ChIP-Seq on regenerating liver harvested 12 h after partial hepatectomy (PH) from mice treated with supplemental parenteral dextrose (to delay onset of PH-induced hypoglycemia) or vehicle (as control). Examination of the effect of delaying PH-induced hypoglycemia on h...
ORGANISM(S): Mus musculus 
Autophagy Impairment in Retinal Ganglion Cells Following Hypoglycemia in Mice.
MicroRNA-7a overexpression in VMH restores the sympathoadrenal response to hypoglycemia
SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6- deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained un...
ORGANISM(S): Mus musculus 
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