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ProteomicsProteomic analysis and functional validation reveal distinct therapeutic capabilities related to priming of mesenchymal stromal/stem cells with IFN-γ and hypoxia: potential implications for their clinical use
Mesenchymal stromal/stem cells (MSCs) are a heterogeneous population of multipotent cells that can be obtained from various tissues, such as dental pulp, adipose tissue, bone marrow and placenta. MSCs have gained importance in the field of regenerative medicine because of their promising role in cel...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD052445 | Pride
Msc priming Msc therapeutic properties Proteomic analysis Msc paracrine effects Placenta-derived mesenchymal stromal/stem cells Ifn-γ priming Hypoxia priming 
GenomicsHypoxia-induced priming of microglial inflammatory gene expression is associated with TLR4 signaling H3K4me3 enrichment
Hypoxia-induced priming of microglial inflammatory gene expression is associated with TLR4 signaling H3K4me3 enrichment
PRJNA428767 | ENA
UnknownPeripheral macrophages contribute to nociceptor priming in mice with chronic intermittent hypoxia.
Not available
S-EPMC11412124 | biostudies-literature
UnknownShort Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities.
Not available
S-EPMC4933215 | biostudies-literature
UnknownDual IFN-γ/hypoxia priming enhances immunosuppression of mesenchymal stromal cells through regulatory proteins and metabolic mechanisms.
Not available
S-EPMC6197483 | biostudies-literature
ProteomicsUSP9X coordinates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via maintaining cancer stem cells
Widespread intraperitoneal metastases and chemoresistance has made ovarian cancer the leading cause of gynecological malignancy–related deaths, wherein TGF-β signaling plays the pivotal role by promoting cancer stem cells (CSCs) activity. Whereas, how the signaling is activated and how to target TGF...
ORGANISM(S): Homo Sapiens 
2024-03-08 | PXD050476 |
TranscriptomicsShort-term hypoxia synergizes with interleukin 15 priming in driving glycolytic gene transcription and supports human natural killer cell activities.
Natural killer (NK) cells induce apoptosis in infected and transformed cells and produce immunoregulatory cytokines. At this, NK cells operate in inflammatory and tumor environments low in oxygen (hypoxic) and with immunosuppressive properties. In vitro studies of NK cells are, however, commonly per...
ORGANISM(S): Homo sapiens 
2016-05-09 | GSE70214 | GEO
ProteomicsPriming-Dependent Modulation of Secretome in Placenta- and Adipose-Derived Mesenchymal Stromal/Stem cells: Toward Cell-Free Immunoregenerative Therapies for Osteoarticular Disorders
Age-related bone degeneration is driven by structural deterioration, chronic inflammation, and impaired regenerative capacity, leading to an increased incidence of osteoarticular disorders. Mesenchymal stromal/stem cells (MSCs) have emerged as promising therapeutic candidates due to their immunomodu...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD068866 | Pride
Placenta-derived mscs Exosomal microrna Mesenchymal stromal cells Cytokine priming Adipose-derived mscs Secretome Proteomics Extracellular vesicles Osteogenesis Chondrogenesis 
UnknownWaterlogging Priming Enhances Hypoxia Stress Tolerance of Wheat Offspring Plants by Regulating Root Phenotypic and Physiological Adaption.
Not available
S-EPMC9370225 | biostudies-literature
ProteomicsHypoxia response in barley - proteomics analysis
Hypoxia stress (<1% oxygen) followed by reoxygenation, is accompanied by formation of reactive oxygen species (ROS) and nitric oxide (NO), which act as signaling molecules, but also cause nitro-oxidative stress. The NO concentration is regulated by phytoglobins (formerly hemoglobins) in the NO cycle...
ORGANISM(S): Hordeum vulgare (Barley) 
2020-03-02 | PXD017103 | Pride
Barley Hypoxia Lc-ms/ms 
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