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MetabolomicsTaurine ameliorates oxidative stress of BMSCs and promotes osteogenesis in irradiated jaws
Osteoradionecrosis of the jaw (ORNJ) is a complication after head and neck radiotherapy that severely affects patients’ quality of life. Currently, an overall understanding of microenvironmental factors of ORNJ is still lacking. Here, we reveal the activation of taurine metabolism in irradiated mand...
2024-07-08 | MTBLS10284 | MetaboLights
MetabolomicsHypoxia promotes osteogenesis via regulating the acetyl-CoA-mediated mito-nuclear communication.
Not available
ORGANISM(S): Mus musculus 
ST002242 | MetabolomicsWorkbench
TranscriptomicseHSP70 promotes osteogenesis of hMSCs through activating ERK signaling pathway
Heat shock proteins are highly conserved proteins that, when produced intracellularly, protect stress exposed cells. It has been suggested that extracellular Hsp70 has both protective and deleterious effects. Our study showed eHSP70 increased the ALP activity, promoted mineralization and up-regulate...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-71080 | biostudies-arrayexpress
TranscriptomicsEctopic Hedgehog signalling causes cleft palate and defective osteogenesis
In this study, we have investigated the molecular basis of Shh signalling during development of the secondary palate and how CNCC patterning and fate is influenced by the Shh signalling network. Using a gain-of-function mouse model to activate Smoothened (R26SmoM2) signalling in the palatal mesenchy...
ORGANISM(S): Mus musculus 
2018-10-02 | E-MTAB-5518 | biostudies-arrayexpress
ProteomicsMulti-Omic analyses reveal aberrant differentiation trajectory with WNT1 Loss-of-Function in type XV osteogenesis imperfecta
Osteogenesis imperfecta (OI) is a serious genetic bone disorder characterized by congenital low bone mass, deformity and frequent fractures. Type XV OI is a moderate to severe form of skeletal dysplasia caused by WNT1 mutations. In this cohort study from southern China, we summarized the clinical ph...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD050841 | Pride
Human Bone Osteogenesis imperfecta 
GenomicsOsteogenesis Chip-Seq
Osteogenesis Chip-Seq
PRJEB4494 | ENA
GenomicsOsteogenesis RNA-Seq
Osteogenesis RNA-Seq
PRJEB4496 | ENA
UnknownA multicenter study to evaluate pulmonary function in osteogenesis imperfecta.
Not available
S-EPMC6235719 | biostudies-literature
ProteomicsTemporal Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins during Osteogenic Differentiation of Human Embryonic Stem Cells
Osteogenesis is the process of bone formation and is modulated by multiple regulatory networks. With the rapid development of the epitranscriptomics field, RNA modifications and their reader, writer, and eraser (RWE) proteins are shown to be involved in the regulation of various biological processes...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD039249 | Pride
Epitranscriptomic reader Writer and eraser Osteogenesis 
ProteomicsCharacterization of the Angiogenic and Proteomic Features of Circulating Exosomes in a Canine Mandibular Model of Distraction Osteogenesis
While distraction osteogenesis (DO) can be an extremely effective approach to treating extensive bone defects, it entails a very long treatment period. The present study was designed with the goal of clarifying the mechanisms underlying the angiogenic and osteogenic activities characteristic of DO s...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2025-05-13 | PXD050531 | Pride
Characterization Circulating exosomes Proteomic Angiogenic Distraction osteogenesis 
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