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ProteomicsInteraction proteomics of the human solute carrier (SLC) transporter superfamily
Solute carrier (SLC) transporters form a major superfamily which transport a wide range of substrates across cellular and organellar membranes. The superfamily consists of about 450 members and includes passive transporters, antiporters and symporters. To ensure the homeostatic regulation of metabol...
ORGANISM(S): Homo sapiens (Human) 
2025-03-03 | PXD055605 | Pride
Ppi resource Human slc Ap-ms Large-scale ap-ms 
UnknownCorrelation between human ether-a-go-go-related gene channel inhibition and action potential prolongation.
Not available
S-EPMC5573420 | biostudies-literature
ProteomicsInteraction proteomics of wildtype SLC16A6 (MCT7) and phospho-variants
The solute carrier (SLC) transporter superfamily are important coordinators of metabolic and cellular homeostasis. Despite their importance for cellular homeostasis, SLCs remain a largely understudied group of proteins regarding their protein interactome. Thus, we conducted a largescale interactome ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-03 | PXD055141 | Pride
Phosphodegron Slc16a6 phsopho-variants Ap-ms 
UnknownDifferential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors.
Not available
S-EPMC8607904 | biostudies-literature
UnknownSmall molecule absorption by PDMS in the context of drug response bioassays.
Not available
S-EPMC5240851 | biostudies-literature
ProteomicsQuantitative proteome profiling of parental cell lines used in the RESOLUTE project (https://re-solute.eu).
To enable successful SLC function deorphanization we aimed to select a minimal number of cell lines covering expression of as many SLCs as possible. Based on a publicly available RNA-Seq dataset of 675 cell lines (Klijn C. et al, Nat. Biotechnol. 2015) we selected a set of 6 adherent human cell line...
ORGANISM(S): Homo sapiens (Human) 
2024-04-29 | PXD051747 | Pride
Lc-msms Solute carriers Resolute Human Lfq Slc 
UnknownFrom receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action.
Not available
S-EPMC5658448 | biostudies-literature
UnknownPutative role of the adenosine A(3) receptor in the antiproliferative action of N (6)-(2-isopentenyl)adenosine.
Not available
S-EPMC3224645 | biostudies-literature
UnknownWhich compound to select in lead optimization? Prospectively validated proteochemometric models guide preclinical development.
Not available
S-EPMC3223189 | biostudies-literature
UnknownIdentification of novel small molecule inhibitors for solute carrier SGLT1 using proteochemometric modeling.
Not available
S-EPMC6689890 | biostudies-literature
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