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TranscriptomicsEffect of microgravity on brain gene expression in mice
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body together with an elimination of normal head-to-foot hydrostatic pressure gradients. To assess brain gene profile changes ass...
ORGANISM(S): Mus musculus 
2008-08-07 | E-GEOD-12312 | biostudies-arrayexpress
TranscriptomicsConnexin-dependent transcellular transcriptomic networks in mouse brain
Microarray experiments have generally focused on magnitude of gene expression changes in pathological conditions, thereby using the method as a high throughput screen to identify candidate marker genes and/or to validate phenotypic differences. We have used novel strategies to extract additional in...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-6355 | biostudies-arrayexpress
TranscriptomicsTranscriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes
Trypanosoma cruzi infection is a major cause of cardiomyopathy. Gene profiling studies of hearts from infected mice have revealed prominent changes in gene expression within many functional pathways. This variety of transcriptomic changes in infected mice raises the question of whether gene express...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-17330 | biostudies-arrayexpress
TranscriptomicsSex-dependent gene regulatory networks of the heart rhythm
Expression level, control and intercoordination of 66 selected heart rhythm determinant (HRD) genes were compared in atria and ventricles of 4 male and 4 female adult mice. We found that genes encoding various adrenergic receptors, ankyrins, ion channels and transporters, connexins and other compone...
ORGANISM(S): Mus musculus 
2009-08-12 | E-GEOD-17324 | biostudies-arrayexpress
TranscriptomicsCX43 heterozygous, Cx43 null and Cx32 null vs wildtype neonatal mouse brain
Cy3-labeled cDNA from brains of neonatal C57BL Cx43 null, Cx43 heterozygous and Cx32 null mice were compared among themselves and to Cy3-labeled cDNA from brains of neonatal C57BL wildtype mice through Cy5-labeled sample reference prepared at once for the entire experiment from aorta, brain, heart, ...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-1954 | biostudies-arrayexpress
TranscriptomicsCX43 KO vs WT cortical astrocytes
RNA samples extracted from astrocytes cultured from wild type and Cx43 null neonatal mice were dye labeled and individually co-hybridized with a reference of labeled cDNAs pooled from a variety of tissues on eight gene arrays containing 8975 mouse DNA sequences
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-580 | biostudies-arrayexpress
TranscriptomicsConnexin43 null vs wildtype neonatal mouse HEART
Cy3-labeled cDNA obtained from four pools of three hearts of neonatal C57BL Cx43 null mice were compared to Cy3-labeled cDNA obtained from four pools of three hearts of neonatal C57BL wildtype mice through Cy5-labeled sample reference prepared at once for the entire experiment from aorta, brain, hea...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-1961 | biostudies-arrayexpress
TranscriptomicsTranscriptomic alterations induced by AT-EAE in mouse spinal cord
We compared RNA samples extracted from spinal cords of control (C) and AT-EAE (E) mice using the "Multiple Yellow" strategy. 4 distinct C-extracts were hybridized with two slides and 4 distinct E-extracts with other two slides, and the green/red normalized signals were compared separately and the E/...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2446 | biostudies-arrayexpress
TranscriptomicsHaploinsufficiency in bromodomain containing 2 (Brd2) gene remodels synaptic transmission in male mouse striatum
Our previous work confirmed that Brd2+/- mouse presents the sex specific characteristics of juvenile myoclonic epilepsy, a subsyndrome of idiopathic generalized epilepsy. Here, we investigated the role of Brd2 gene in modulating the genomic fabrics responsible for the glutamatergic, GABAergic, dopam...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-72562 | biostudies-arrayexpress
TranscriptomicsHaploinsufficiency in bromodomain containing 2 (Brd2) gene remodels synaptic transmission in female mouse striatum in a sex-specific manner
Our previous work showed that Brd2+/- mouse models the sex specific characteristics of juvenile myoclonic epilepsy, a subsyndrome of idiopathic generalized epilepsy. Here, we investigated a role of Brd2 gene in modulating the genomic fabrics responsible for the glutamatergic, GABAergic, dopaminergic...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-72563 | biostudies-arrayexpress
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