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Cellular senescence is a stress-induced permanent cell cycle arrest typically accompanied by expression of the cyclin-dependent kinase inhibitor p16. Recent studies have suggested that p16-expressing senescent cells accumulate in the body with age and play a causative role in aging. Various stresses...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD036980 | Pride
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, yet the molecular events underlying its early development are poorly understood. Here, we identify fibroblast growth factor 21 (FGF21), secreted from oncogenic hepatocytes, as a key inducer of cell competit...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2026-10-05 | PXD065286 | Pride
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