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ProteomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but, unlike luminal Rank, the contribution of basal Rank signaling to MG homeostasis remains poorly studied. We have combined timely regulated ...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD054102 | Pride
Breast cancer Basal cell Identity infidelity Rank Mouse Mammary gland 
ProteomicsRank signaling drives basal cell-lineage infidelity leading to mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but unlike that of luminal, the contribution of basal Rank signaling to mammary gland homeostasis remains poorly studied. Combining timely-regu...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD058134 | Pride
Rank signaling Phosphorylation Tumorogenesis 
UnknownReduced Abd-B Hox function during kidney development results in lineage infidelity.
Not available
S-EPMC5940526 | biostudies-literature
TranscriptomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but, unlike luminal Rank, the contribution of basal Rank signaling to MG homeostasis remains poorly studied. We have combined timely regulated ...
ORGANISM(S): Mus musculus 
2026-01-16 | GSE272902 | GEO
GenomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but, unlike luminal Rank, the contribution of basal Rank signaling to MG homeostasis remains poorly studied. We have combined timely regulated ...
ORGANISM(S): Mus musculus 
2026-01-16 | GSE272968 | GEO
GenomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Disruption of basal cell identity by Rank signaling drives mammary tumorigenesis
PRJNA1139209 | ENA
GenomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Disruption of basal cell identity by Rank signaling drives mammary tumorigenesis
PRJNA1139725 | ENA
GenomicsSingle-cell chromatin accessibility data using scATAC-seq
A single hematopoietic stem cell can give rise to all blood cells with remarkable fidelity. Here, we define the chromatin accessibility and transcriptional landscape controlling this process in thirteen primary cell types that traverse the hematopoietic hierarchy. Exploiting the finding that enhance...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-74310 | biostudies-arrayexpress
TranscriptomicsUnstranded RNA sequencing data
A single hematopoietic stem cell can give rise to all blood cells with remarkable fidelity. Here, we define the chromatin accessibility and transcriptional landscape controlling this process in thirteen primary cell types that traverse the hematopoietic hierarchy. Exploiting the finding that enhance...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-74246 | biostudies-arrayexpress
GenomicsATAC-seq data
A single hematopoietic stem cell can give rise to all blood cells with remarkable fidelity. Here, we define the chromatin accessibility and transcriptional landscape controlling this process in thirteen primary cell types that traverse the hematopoietic hierarchy. Exploiting the finding that enhance...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-74912 | biostudies-arrayexpress
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