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TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
TranscriptomicsIdentification of genes regulated by the RANK IVVY motif in macrophages
Identification of genes regulated by RANK RVVY motif in macrophages by gene expression analysis of TNFR1-/-R2-/- BMMs expressing a chimeric receptor consisting of the external domain of mouse TNFR1 linked to the transmembrane and intracellular domain of mouse RANK (WT) and NFR1-/-R2-/- BMMs expressi...
ORGANISM(S): Mus musculus 
2011-08-19 | E-GEOD-17745 | biostudies-arrayexpress
GenomicsCD45- sorted tumor cells from RANK+/+ and RANK-/- MMTV_PYMT late carcinomas
CD45- sorted tumor cells from RANK+/+ and RANK-/- MMTV_PYMT late carcinomas
PRJNA489283 | ENA
TranscriptomicsThe RANK/RANKL axis controls vascular dynamics in the bone marrow
Receptor activator of nuclear factor kappa B ligand (RANKL) is an essential cytokine that induces osteoclastic differentiation by monocyte-macrophage lineage precursors. Here, we showed that in addition to its conventional action, RANKL controls vascular permeability in the bone marrow, where it fac...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15929 | biostudies-arrayexpress
ProteomicsRank signaling drives basal cell-lineage infidelity leading to mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but unlike that of luminal, the contribution of basal Rank signaling to mammary gland homeostasis remains poorly studied. Combining timely-regu...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD058134 | Pride
Rank signaling Phosphorylation Tumorogenesis 
TranscriptomicsNovel Rank-Based Statistical Methods Reveal MicroRNAs with Differential Expression in Multiple Cancer Types
The data collected in this study consisted of 32 paired samples of cancerous and normal origins from 14 different patients and 8 different cancer types. Each pair of samples was taken from different parts of the same tissue in the same patient - one collected and extracted from the tumor and one col...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-14985 | biostudies-arrayexpress
TranscriptomicsThe RANK IVVY Motif-regulated Genes in Osteoclastogenesis
By carrying out a systematic structure/function study of the RANK cytoplasmic domain, we previously identified a specific 4-a.a. RANK motif (IVVY535-538) which plays a critical role in osteoclastogenesis by mediating commitment of macrophages to the osteoclast lineage. We have recently validated the...
ORGANISM(S): Mus musculus 
2011-07-05 | E-GEOD-30160 | biostudies-arrayexpress
ProteomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but, unlike luminal Rank, the contribution of basal Rank signaling to MG homeostasis remains poorly studied. We have combined timely regulated ...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD054102 | Pride
Breast cancer Basal cell Identity infidelity Rank Mouse Mammary gland 
GenomicsBulk RNA sequencing of RANK-overexpressing MOVAS cells
Bulk RNA sequencing of RANK-overexpressing MOVAS cells
PRJNA1518051 | ENA
TranscriptomicsGene expression analysis of transcriptome changes regulated by RANKL-RANK signaling in macrophage cell line RAW 264.7
Bone remodeling relies on the precise developmental control of osteoclasts that resorb bone and osteoblasts that lay down fresh bone matrix. The hematopoietically derived osteoclast follow a tigthly controlled genetic program where specific genes are up-regulated to aid bone resorption.Some of them ...
ORGANISM(S): Mus musculus 
2010-08-24 | E-GEOD-21639 | biostudies-arrayexpress
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