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Mutant IDH inhibitors induce lineage differentiation in IDH-mutant Oligodendroglioma II
Mutant IDH inhibitors induce lineage differentiation in IDH-mutant Oligodendroglioma I
Mutant IDH inhibitors induce lineage differentiation in IDH-mutant Oligodendroglioma III
Adult-type diffuse gliomas comprise IDH-mutant astrocytomas, IDH-mutant 1p/19q codeleted oligodendrogliomas (ODG), and IDH-wildtype glioblastomas (GBM). GBM display genome instability, which may result from two genetic events leading to massive chromosome alterations: chromothripsis (CT) and whole-g...
ORGANISM(S): Homo sapiens 
Background: Aggressiveness guides treatment in IDH-mutant gliomas. Objective grading of oligodendrogliomas is therefore urgently needed. Material and Methods: 211 primary and recurrent resections from 111 oligodendroglioma patients were collected, complemented with 91 samples for validation. Samples...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD070222 | Pride
This multi-site, Phase 1/2 clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO212 for the treatment of patients with radiographically-confirmed progression of Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype, and the safety,...
Mutant IDH disables p53 tumor suppression [CUT&RUN]
Mutant IDH disables p53 tumor suppression [RNA-seq]
Modeling therapy sequencing in IDH-mutant glioma reveals that the mutant IDH inhibitor vorasidenib improves chemoradiation response
Mutant IDH modulates suppressive myeloid populations in malignant glioma
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