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MetabolomicsAberrant accumulation of cyclin D1 rewires glutamine metabolism via loss of IDH3 generating metabolic vulnerability in ESCC and HNSCC

Excessive cyclin D1 accumulation is a frequent oncogenic event in head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC). Although classically associated with enhanced proliferation and genomic instability, we reveal that cyclin D1 dysregulation induces unexpe...

2026-08-24 | MTBLS13687 | MetaboLights
MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
GenomicsExpression data of glucose-restricted or IDH3-knocked down 3T3-L1 cells.
Expression data of glucose-restricted or IDH3-knocked down 3T3-L1 cells.
PRJNA1106621 | ENA
UnknownIDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial Ca2+ uptake during hypocapnia.
Not available
S-EPMC5596584 | biostudies-literature
ProteomicsIDH3 serves as a redox switch that regulates energy metabolism and contractility in the heart under oxidative stress
Redox signaling and cardiac function are tightly linked. Still, it is largely unknown which specific protein targets are affected by reactive oxygen species (ROS) that underly the impaired inotropic effect in oxidative stress. Here, we combined a new chemogenetic mouse model (HMC HyPer-DAO transgeni...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-15 | PXD033119 | Pride
Ros Total reversible oxidation Hyper-dao mice 
ProteomicsIDH3 serves as a redox switch that regulates mitochondrial energy metabolism and contractility in the heart under oxidative stress
Redox signaling and cardiac function are tightly linked. Still, it is largely unknown which specific protein targets are affected by reactive oxygen species (ROS) that underly the impaired inotropic effect in oxidative stress. Here, we combined a new chemogenetic mouse model (HMC HyPer-DAO transgeni...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-21 | PXD037987 | Pride
Heart Mouse Hyperdao Redox proteomics 
ProteomicsMitoproteomics of neuronal mitochondria of EAE mice
Inflammation in the central nervous system (CNS) can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell type-specific mitochondrial proteomics with in vivo biosensor imaging to dissec...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-18 | PXD032363 | Pride
Mitochondria Idh3 Neurons 
UnknownStructures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.
Not available
S-EPMC9731866 | biostudies-literature
UnknownIsocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability.
Not available
S-EPMC9478456 | biostudies-literature
TranscriptomicsExpression data of glucose-restricted or IDH3-knocked down 3T3-L1 cells.
Adipose tissue remodels via hypertrophy or hyperplasia in response to nutrient status, but the mechanisms governing these expansion modes remain unclear. Here, we identify a nutrient-sensitive epigenetic circuit linking glucose metabolism to chromatin remodeling during adipogenesis. Upon glucose sti...
ORGANISM(S): Mus musculus 
2025-07-20 | GSE266316 | GEO
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