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TranscriptomicsSerial Analysis of Gene Expression molecular signature for disease progression in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrosing interstitial lung disease that is unresponsive to current therapy. While it carries a median survival of less than 3 years its rate of progression varies widely between patients. We hypothesized that studying the gene express...
ORGANISM(S): Homo sapiens 
2009-04-07 | E-GEOD-11665 | biostudies-arrayexpress
TranscriptomicsmiRNA expression data in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is an untreatable fibrotic lung disease characterized by fibroblast proliferation and epithelial mesenchymal transition. The expression and role of microRNAs (miRNA) has not been studied in IPF. Using miRNA expression microarrays we identified 46 differentially ex...
ORGANISM(S): Homo sapiens 
2010-04-23 | E-GEOD-13316 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is an untreatable fibrotic lung disease characterized by fibroblast proliferation and epithelial mesenchymal transition. Using miRNA expression microarrays we identified 96 differentially expressed miRNA in IPF lungs which included let-7d, miR-30 family, miR-29 fa...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27430 | biostudies-arrayexpress
TranscriptomicsBleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: A model for “active” disease
Genomic profiling of RNA from cultured human fibroblasts of donor samples in the 10-14th passage was carried out to determine expression changes in the fibroblasts of individual with different degrees of pulmonary fibrosis. Donors consisted of individuals with rapid progressing pulmonary fibrosis, s...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-44723 | biostudies-arrayexpress
TranscriptomicsGenomic Phenotype Of Non-Cultured IPF Fibroblasts
The activated fibroblast is the central effector cell for the progressive fibrotic process that characterizes idiopathic pulmonary fibrosis (IPF). An understanding of the genomic phenotype of this cell in isolation is essential to the understanding of disease pathogenesis and is integral to strategi...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-17978 | biostudies-arrayexpress
TranscriptomicsValidated Gene Expression Signatures of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease that is difficult to diagnose and follows an unpredictable clinical course. The object of this study was to develop a predictive gene signature model of IPF from whole lung tissue. We collected whole lung samples from 11 IPF pat...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-24206 | biostudies-arrayexpress
ProteomicsO-GlcNAc Containing Proteins in Normal and Idiopathic Pulmonary Fibrosis Human Fibroblasts
Isolated normal and IPF fibroblasts were homogenized in cold MilliQ water using a bullet blender. Samples were centrifuged and inhibitors were added: HALT (Thermo Fisher Scientific), Z-Pugnac (Tocris), Thiamet G (Cayman Chemicals), and benzonase (E1014, Millipore, Sigma). O-GlcNAc enzymatic labeling...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-21 | MSV000093453 | MassIVE
TranscriptomicsSpatial transcriptomics (Visium, 10x Genomics) data for human Idiopathic Pulmonary Fibrosis (IPF) and control lung tissue
Visium (10x Genomics) spatially resolved transcriptomics data generated from normal and Idiopathic Pulmonary Fibrosis (IPF) lung parenchyma tissues collected from human donors. The fresh-frozen tissues that were analyzed were from four healthy control (HC) subjects and from four IPF patients. For ea...
ORGANISM(S): Homo sapiens 
2024-05-28 | E-MTAB-14121 | biostudies-arrayexpress
TranscriptomicsIdentification of the gene expression in IPF lung fibroblasts after demethylation
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a key role. We used microarrays to see the gene expression in IPF fibroblasts after demethyl...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-69764 | biostudies-arrayexpress
ProteomicsHuman Epididymis Protein 4 Promotes Aberrant Epithelial-Fibroblast Crosstalk in Pulmonary Fibrosis
Invasive lung myofibroblasts are the main cause of tissue remodeling in idiopathic pulmonary fibrosis (IPF). A key mechanism contributing to this important feature is aberrant crosstalk between the abnormal/injured lung epithelium and pulmonary fibroblasts. Here, we demonstrated that lungs from pati...
ORGANISM(S): Homo Sapiens 
2024-12-17 | PXD058959 |
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