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Proteomic analysis of antigen-specific serum IgG repertoires from healthy adults vaccinated with either mRNA-1010 or Fluarix quadrivalent influenza vaccines. Serum IgG was characterized using Ig-Seq, an approach integrating immunoglobulin proteomics with B cell receptor sequencing to identify and qu...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD077942 | Pride
The goal of this study was to investigate the role of intragenic CTCF in alternative pre-mRNA splicing through a combined CTCF-ChIP-seq and RNA-seq approach. CTCF depletion led to decreased inclusion of weak upstream exons. CTCF ChIP-seq was performed in BJAB and BL41 B cell lines and normalized rel...
ORGANISM(S): Homo sapiens 
Ig-seq of Propithecus coquereli
Intra-Vk Cluster Recombination Shapes the Ig Kappa Locus Repertoire [END-seq]
Intra-Vk Cluster Recombination Shapes the Ig Kappa Locus Repertoire [ChIP-seq]
During activation, T cells integrate multiple signals from APCs and cytokine milieu. The blockade of these signals can have clinical benefits as exemplified by CTLA4-Ig, which blocks interaction of B7 co-stimulatory molecules on APCs with CD28 on T cells. Variants of CTLA4-Ig, abatacept and belatace...
ORGANISM(S): Homo sapiens 
Proteomic Ig-SEQ identification of SARS-COV-2 specific antibodies from serum of two convalescent patients during the first wave of the COVID-19 pandemic. Total IgG was isolated from serum, digested with IdeS protease to generate F(ab)2 fragments, and subjected to antigen affinity chromatography usin...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046829 | Pride
IG-DMR escapes from global hypomethylation during adult neural stem cells reprogramming [RNA-seq]
IG-DMR escapes from global hypomethylation during adult neural stem cells reprogramming [MeDIP-seq]
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