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ProteomicsMolecular basis of Fab-dependent IgA antibody recognition by gut-associated metallopeptidases
Immunoglobulin A (IgA) is essential for mucosal immunity and is implicated in autoimmune diseases like IgA nephropathy (IgAN). Certain pathogenic and commensal bacteria produce IgA proteases (IgAPs) that selectively cleave IgA, potentially aiding bacterial colonization and offering therapeutic avenu...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD065112 | Pride
Iga Iga protease Metallopeptidase 
ProteomicsSerum proteomic analysis of circulating IgA1-containing immune complexes in patients with IgA nephropathy
IgA nephropathy (IgAN) is an autoimmune disease that involves galactose-deficient IgA1 (Gal-deficient IgA1) recognized by autoantibodies to form circulating immune complexes (IgA1-IC). Some of these complexes deposit in the glomeruli and induce kidney injury. Gal-deficient IgA1 alone is not sufficie...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD055562 | Pride
Proteomics Lc-ms Complement Orbitrap Raw Immune complexes Serum Iga nephropathy Glomerular disease 
UnknownChimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy.
Not available
S-EPMC9063903 | biostudies-literature
UnknownDifferential distribution of IgA-protease genotypes in mucosal and invasive isolates of Haemophilus influenzae in Sweden.
Not available
S-EPMC6249890 | biostudies-literature
UnknownBacterial IgA protease-mediated degradation of agIgA1 and agIgA1 immune complexes as a potential therapy for IgA Nephropathy.
Not available
S-EPMC4971536 | biostudies-literature
UnknownHyperinvasive Meningococci Induce Intra-nuclear Cleavage of the NF-κB Protein p65/RelA by Meningococcal IgA Protease.
Not available
S-EPMC4524725 | biostudies-literature
TranscriptomicsSingle-cell RNA-seq profiling reveals novel insights in immune-complex deposition and epithelium transition in IgA nephropathy
IgA nephropathy represents the most prevalent chronic nephrosis worldwide. However, pathogenesis about IgA deposition and end-stage renal failure is still not well defined. Using single-cell RNA-seq, we identified the mesangial membrane receptor for IgA, which collaborates with increased extracellul...
ORGANISM(S): Homo sapiens 
2021-07-06 | GSE127136 | GEO
UnknownIgA1 Protease Treatment Reverses Mesangial Deposits and Hematuria in a Model of IgA Nephropathy.
Not available
S-EPMC5004657 | biostudies-literature
ProteomicsCharacterization of MdpS: An In-depth Analysis of a MUC5B-Degrading Protease from Streptococcus oralis
Oral biofilms, comprising hundreds of bacteria and other microorganisms on oral mucosal and dental surfaces, play a central role in oral health and disease dynamics. Streptococcus oralis, a key constituent of these biofilms, contribute significantly to their formation, serving as an early colonizer ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-18 | PXD046810 | Pride
Serine protease O-glycosylation Mucin degradation Oral biofilm Muc5b Streptococcus oralis 
UnknownA Novel Broad-Spectrum Elastase-Like Serine Protease From the Predatory Bacterium Bdellovibrio bacteriovorus Facilitates Elucidation of Site-Specific IgA Glycosylation Pattern.
Not available
S-EPMC6510308 | biostudies-literature
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