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MetabolomicsSalivary MUC5B Modulation of Glucose Metabolism in Early Oral Biofilms
To investigate how early mono- and dual species biofilms of oral Actinomyces naeslundii and Streptococcus gordonii clinical isolates metabolized glucose in the presence of the complex salivary mucin MUC5B, this study employed NMR-based metabolomics with interpretation of network integration. Untarge...
2024-09-11 | MTBLS10078 | MetaboLights
MetabolomicsSynergistic metabolism of salivary MUC5B in oral commensal bacteria during early biofilm formation

Bacterial metabolism in oral biofilms is comprised of complex networks of nutritional chains and biochemical regulations. These processes involve both intraspecies and interspecies networks as well as interactions with components from host saliva, gingival crevicular fluid, and dietary intake. In...

2023-10-30 | MTBLS8370 | MetaboLights
ProteomicsCharacterization of MdpS: An In-depth Analysis of a MUC5B-Degrading Protease from Streptococcus oralis
Oral biofilms, comprising hundreds of bacteria and other microorganisms on oral mucosal and dental surfaces, play a central role in oral health and disease dynamics. Streptococcus oralis, a key constituent of these biofilms, contribute significantly to their formation, serving as an early colonizer ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-18 | PXD046810 | Pride
Serine protease O-glycosylation Mucin degradation Oral biofilm Muc5b Streptococcus oralis 
ProteomicsPeptide and MUC5B hydrolysis by the Mucin Degrading Protease (MdpL) from Limosilactobacillus fermentum
MUC5B is the predominant glycoprotein in saliva and is instrumental in the establishment and maintenance of multi-species eubiotic biofilms in the oral cavity. Investigations of the aciduric Lactobacillaceae family, and its role in biofilms emphasizes the diversity across different genera of the pro...
ORGANISM(S): Homo sapiens (Human) 
2023-03-22 | PXD039681 | Pride
Iob Mdpl Limosilactobacillus fermentum Muc5b Neuromedin Mog Lc-msms 
GenomicsRNA-Seq of GBS MUC5B
RNA-Seq of GBS +/- MUC5B
PRJEB49122 | ENA
GenomicsA hPSC system for characterizing MUC5B-expressing airway epithelia
A hPSC system for characterizing MUC5B-expressing airway epithelia
PRJNA835444 | ENA
ProteomicsMdpS and MdpS2 structurally and functionally diverge to regulate Streptococcus oralis mucin degradation
The human oral cavity harbors a diverse microbial community, with oral streptococci, particularly the Streptococcus mitis group, playing a pivotal role in biofilm formation and oral health. Among these, Streptococcus oralis is a key early colonizer that stabilizes oral biofilms. Here, we identify tw...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD062603 | Pride
Muc5b Streptococcus oralis Biofilm dynamics Mucin degrading proteases Oral microbiome Mucin degradation 
TranscriptomicsThe MUC5B IPF risk variant promotes a distal airway secretory phenotype and loss of alveolar markers
The dominant risk factor for the development of idiopathic pulmonary fibrosis (IPF) is a common variant in the promoter region of the airway mucin MUC5B, variant rs35705950. The MUC5B promoter variant enhances MUC5B expression in the terminal respiratory bronchiole, where it is normally absent. We p...
ORGANISM(S): Homo sapiens 
2024-07-29 | GSE267521 | GEO
ProteomicsThe MUC5B promoter variant results in proteomic changes in the non-fibrotic lung
The gain-of-function MUC5B promoter varaint is the dominant risk for IPF development. Herein, we performed laser capture microdissection coupled mass spectrometry to isolate the characteristic histopathological lesions of IPF, the normal-appearing alveoli/small airways, and epithelium overlying fibr...
ORGANISM(S): Homo sapiens (Human) 
2025-06-13 | PXD058626 | Pride
Human Ipf Lung Fibrosis Muc5b 
ProteomicsCharacterization of MdpS: An In-depth Analysis of a MUC5B-Degrading Protease from Streptococcus oralis
Oral biofilms, comprising hundreds of bacteria and other microorganisms on oral mucosal and dental surfaces, play a central role in oral health and disease dynamics. Streptococcus oralis, a key constituent of these biofilms, contribute significantly to their formation, serving as an early colonizer ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD046954 | Pride
Serine protease O-glycosylation Mucin degradation Oral biofilm Muc5b Streptococcus oralis 
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