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ProteomicsHuman IgG1 (B-cell receptor) Fc peptide glycan analysis, LC-MS
Since few data are available on glycans expressed by human BCRs, we aimed to analyze the Fc glycans of membrane-bound IgG after BCR capture and tryptic digestion by LC-MS. For this purpose, human B-cell lines from Burkitt Lymphoma (Ramos) expressing IgG1-BCRs in the presence or absence of Fc glycans...
ORGANISM(S): Homo sapiens (Human) 
2023-12-11 | PXD047089 | Pride
Human B-cell receptor Igg1 fc peptide glycans Lc-ms 
ProteomicsSite-specific analysis of CD16a and CD32a N-glycosylation from monocytes display donor variability which modulate affinity to IgG1 Fc
Glycopeptide mass spectra of CD16a and CD32a from isolated monocytes display donor and site variability. CD16a N-glycosylation composition affects the affinity of IgG1 Fc. Peptide coverage of CD16a was ~85% while CD32a was ~61%.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-26 | MSV000084012 | MassIVE
UnknownIgG antibodies to cyclic citrullinated peptides exhibit profiles specific in terms of IgG subclasses, Fc-glycans and a fab-Peptide sequence.
Not available
S-EPMC4245247 | biostudies-literature
UnknownAntitumor Efficacy of Anti-GD2 IgG1 Is Enhanced by Fc Glyco-Engineering.
Not available
S-EPMC4948116 | biostudies-literature
UnknownSynthetic Glycopeptides Allow for the Quantitation of Scarce Nonfucosylated IgG Fc N-Glycans of Therapeutic Antibody.
Not available
S-EPMC6142058 | biostudies-literature
UnknownSolution structure of deglycosylated human IgG1 shows the role of CH2 glycans in its conformation.
Not available
S-EPMC8204293 | biostudies-literature
ProteomicsRole of N-glycosylation in FcRIIIa interaction with IgG
Immunoglobulins G (IgG) and their Fc gamma receptors (FcγRs) play important roles in our immune system. The conserved N-glycan in the Fc region of IgG1 impacts interaction of IgG with FcγRs and the resulting effector functions, which has led to design of antibody therapeutics with greatly improved a...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-30 | PXD035846 | Pride
Mabs Cd16a Igg N-glycosylation Fc gamma receptors Glycosyltransferases Surface plasmon resonance Glycoengineering 
UnknownComputational insights into O-glycosylation in a CTLA4 Fc-fusion protein linker and its impact on protein quality attributes.
Not available
S-EPMC7734232 | biostudies-literature
UnknownExpression and Display of Glycoengineered Antibodies and Antibody Fragments with an Engineered Yeast Strain.
Not available
S-EPMC8544235 | biostudies-literature
UnknownNon-targeted characterization of attributes affecting antibody-FcγRIIIa V158 (CD16a) binding via online affinity chromatography-mass spectrometry.
Not available
S-EPMC8741291 | biostudies-literature
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