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ProteomicsSPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms. SPOP knockdown leads to spontaneous replication stress and impaired r...
ORGANISM(S): Homo sapiens (Human) 
2018-08-21 | PXD010527 | Pride
Prostate cancer  spop  lc-ms/ms  interactome 
ProteomicsProstate cancer progression: From non-malignant to bone metastasisProstate cancer progression: From non-malignant to bone metastasis
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo sapiens (Human) 
2018-08-21 | PXD009868 | Pride
Prostate cancer bone metastasis  localized prostate cancer  prostatectomy  non-malignant prostate tissue  castration  crpc  lc-ms/ms  silac  quantitative proteomics 
ProteomicsProteomics of prostate cancer patient derived xenografts
A set of 17 prostate cancer patient-derived xenografts (PDX, Lin et al 2014, Cancer research) was analyzed by mass spectrometry-based proteomics to characterize the effects of castration in vivo, and the proteome differences between NEPC and prostate adenocarcinomas.
ORGANISM(S): Homo sapiens (Human) 
2019-09-11 | PXD009636 | Pride
Prostate cancer  neuroendocrine  nepc  castration  crpc  pdx  lc-ms7ms 
ProteomicsThe proteome of localized prostate cancer, part 4
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD004132 | Pride
Super-silac Sax Human Ffpe Q-exactive Fasp Prostate cancer 
ProteomicsThe proteome of localized prostate cancer, part 7
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD004159 | Pride
Super-silac Sax Human Ffpe Q-exactive Fasp Prostate cancer 
ProteomicsThe proteome of localized prostate cancer, part 6
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003636 | Pride
Super-silac Sax Human Ffpe Q-exactive Fasp Prostate cancer 
ProteomicsThe proteome of localized prostate cancer, part 5
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003615 | Pride
Super-silac Sax Human Ffpe Q-exactive Fasp Prostate cancer 
ProteomicsThe proteome of localized prostate cancer, part 3
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003515 | Pride
Super-silac Sax Human Ffpe Q-exactive Fasp Prostate cancer 
ProteomicsThe proteome of localized prostate cancer, part 2
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003452 | Pride
Super-silac Sax Human Ffpe Q-exactive Fasp Prostate cancer 
ProteomicsThe proteome of localized prostate cancer, part 1
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003430 | Pride
Super-silac Sax Human Ffpe Q-exactive Fasp Prostate cancer 
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