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ProteomicsSite-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling
HOIP, the catalytic component of the Linear Ubiquitin chain Assembly Complex (LUBAC), is a critical regulator of inflammation. However, how HOIP itself is regulated to control inflammatory responses is unclear. Here, we discover that site-specific ubiquitination of K784 within HOIP promotes Tumour N...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD021217 | Pride
Site-specific ubiquitination of the e3 ligase hoip regulates apoptosis and immune signaling 
ProteomicsThe linear ubiquitin chain assembly complex LUBAC generates heterotypic ubiquitin chains
The linear ubiquitin chain assembly complex (LUBAC) is the only known ubiquitin ligase that generates linear/Met1-linked ubiquitin chains. One of the LUBAC components, HOIL-1L, was recently shown to catalyse oxyester bond formation between the C-terminus of ubiquitin and some substrates. However, ox...
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD019771 | Pride
E3 ubiquitin ligase/ ester-bond linkage/ hoil-1l/ rbr/ ubiquitin 
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