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TranscriptomicsPGC methylome analysis revealed large, germline-specific mouse hypomethylated DNA domains with unique genomic and epigenomic features
With the goal of understanding the epigenetic regulation required for germ cell-specific gene expression, we devised a method of DNA methylation analysis adapted for a small number of developing germ cells. This microarray-based method provides the genome-wide assay of DNA methylation using a sub-na...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-39895 | biostudies-arrayexpress
TranscriptomicsPGC methylome analysis revealed large, germline-specific mouse hypomethylated DNA domains with unique genomic and epigenomic features [Agilent 44Kx4 Array Expression]
With the goal of understanding the epigenetic regulation required for germ cell-specific gene expression, we devised a method of DNA methylation analysis adapted for a small number of developing germ cells. This microarray-based method provides the genome-wide assay of DNA methylation using a sub-na...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-39892 | biostudies-arrayexpress
TranscriptomicsIncomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse
Mammals have evolved a mechanism to compensate for the difference in the number of X chromosome genes between XX females and XY males by inactivating one of the two X chromosomes in females. This X chromosome inactivation phenomenon is triggered by Xist gene, which is essential for X-inactivation to...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-27373 | biostudies-arrayexpress
TranscriptomicsExpression of Mouse and Human Sense-Antisense Transcript
Increasing numbers of sense–antisense transcripts (SATs), which are transcribed from the same chromosomal location but in opposite directions, have been identified in various eukaryotic species, but the biological meanings of most SATs remain unclear. To improve understanding of natural sense–an...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9581 | biostudies-arrayexpress
TranscriptomicsImpeding Xist expression from the active X chromosome improves mouse somatic cell cloning
Cloning mammals by somatic cell nuclear transfer (SCNT) is highly inefficient because of aberrant genomic reprogramming. In addition to random reprogramming errors, we hypothesized the presence of specific errors as evidenced by common anomalies among clones. We found that Xist, which normally inact...
ORGANISM(S): Mus musculus 
2010-09-16 | E-GEOD-23181 | biostudies-arrayexpress
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