Expression of Mouse and Human Sense-Antisense Transcript

ABSTRACT: Increasing numbers of sense–antisense transcripts (SATs), which are transcribed from the same chromosomal location but in opposite directions, have been identified in various eukaryotic species, but the biological meanings of most SATs remain unclear. To improve understanding of natural sense–antisense transcription, we performed comparative expression profiling of SATs conserved among humans and mice. Using custom oligo-arrays loaded with probes that represented SATs with both protein-coding and non-protein–coding transcripts, we showed that 33% of the 291 conserved SATs displayed identical expression patterns in the two species. Among these SATs, expressional balance inversion of sense–antisense genes was mostly observed in testis at a tissue-specific manner. Northern analyses of

ORGANISM(S): Homo sapiens

SUBMITTER: Rintaro Saito 

PROVIDER: E-GEOD-9581 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress