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MetabolomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
2023-01-31 | MTBLS6337 | MetaboLights
MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
TranscriptomicsComparison of gene expression in the intestinal metaplasia in Cdx2/IL-1beta mice vs IL-1beta alone
Cdx2/IL-1beta mice have less intestinal metaplasia at the squamocolumnar junction thanIL-1beta mice alone. This study was to identify a mechanism for this effect by examining differences in gene expression patterns when Cdx2 is co-expressed. We dissected out intestinal metaplasia nodules from the sq...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-60320 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat chondrocytes treated with glucosamine exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta
Glucosamine proved to be a potent, broad-spectrum inhibitor of IL-1beta. Of the 2,813 genes whose transcription was altered by IL-1beta stimulation (p<0.0001), glucosamine significantly blocked the response in 2,055 (~73%). Glucosamine fully protected the chondrocytes from IL-1-induced expression of...
ORGANISM(S): Rattus norvegicus 
2009-04-23 | E-GEOD-6119 | biostudies-arrayexpress
TranscriptomicsAdult Human Chondrocyte Response to IL-1B
IL-1B is an important cytokine that is often found to be up-regulated during osteoarthritic and rheumatoid joint diseases. It is viewed as a catabolic factor, inducing enzymes that allow for the degradation of the cartilage extracellular matrix and also has essential roles as an autocrine and parac...
ORGANISM(S): Homo sapiens 
2008-05-14 | E-GEOD-11427 | biostudies-arrayexpress
TranscriptomicsRat primary chondrocyte: Control vs. IL-1beta treated
microRNA expression profilings of chondrocytes comparing control untreated cells with cells treated with IL-1beta. Three timepoints included are 6h,12h and 24h. Many microRNAs change their expression patterns owing to IL-1beta stimulation. Some of them are chosen for further investigation. time seri...
ORGANISM(S): Rattus norvegicus 
2012-03-26 | E-GEOD-33310 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Th9 CD4+ T cells differentiated with or without Il-1beta
We report that the Th9 differenciation program is boosted in presence of Il-1beta Examination of the expression profile of Th9 CD4+ T cells after 1 hour and 3 days of differentiation and after in vivo injection
ORGANISM(S): Mus musculus 
2014-05-23 | E-GEOD-54697 | biostudies-arrayexpress
GenomicsChIP-seq analysis of rat pancreatic cells treated with IL-1beta
ChIP-seq analysis of rat pancreatic cells treated with IL-1beta
PRJNA1333405 | ENA
ProteomicsDissecting inflammatory response in intervertebral disc degeneration: triggering of CD44 by IL-1beta
Objectives/Design: Intervertebral Disc (IVD) degeneration has been associated with a chronic inflammatory response, but knowledge on the contribution of distinct IVD cells, namely CD44, to the progression of IVD degeneration remains elusive. Material: Bovine nucleus pulposus (NP) cells. Treatment: ...
ORGANISM(S): Bos taurus (Bovine) 
2024-05-22 | PXD048373 | Pride
Il-1beta Intervertebral disc Nucleus pulposus Cd44 Inflammation 
GenomicsIL-1beta activates IL-17 via calcium
IL-1beta activates IL-17 via calcium
PRJNA484807 | ENA
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