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TranscriptomicsEvaluation of gene expression between CD44+ and CD44- cells in colonospheres
To identify genes that are differentially expressed between CD44+ and CD44- cells in colonospheres, we have employed whole genome microarray expression profiling as a discovery platform. Colonospheres from four colon cancer patients were sorted into CD44+ and CD44- cells using the FACS Aria II Cell ...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-38706 | biostudies-arrayexpress
ProteomicsDissecting inflammatory response in intervertebral disc degeneration: triggering of CD44 by IL-1beta
Objectives/Design: Intervertebral Disc (IVD) degeneration has been associated with a chronic inflammatory response, but knowledge on the contribution of distinct IVD cells, namely CD44, to the progression of IVD degeneration remains elusive. Material: Bovine nucleus pulposus (NP) cells. Treatment: ...
ORGANISM(S): Bos taurus (Bovine) 
2024-05-22 | PXD048373 | Pride
Il-1beta Intervertebral disc Nucleus pulposus Cd44 Inflammation 
TranscriptomicsIdentification of CD44 downstream target genes
CD44 expression has been shown to be enhanced in the liver and white adipose tissue (WAT) during obesity, suggesting a possible regulatory role for CD44 in metabolic syndrome. To study this hypothesis, we compared the gene expression profiles in liver and in WAT between WT and CD44 knockout (CD44KO)...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-43104 | biostudies-arrayexpress
TranscriptomicsEstrogen-modulated gene expression in c-kit+ stem cells and CD44+ stromal cells
The recent interest in the role of bone marrow derived endothelial progenitor cells in the benefits of estrogen on cardiovascular health brought us to evaluate if estrogen could affect cardiac repair more broadly by regulating biological processes involved in the functional organization of the bone ...
ORGANISM(S): Mus musculus 
2008-12-10 | E-GEOD-9098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal, non-tumorigenic breast cancer cells and CD44+CD24-/low tumorigenic breast cancer cells to generate a invasiveness gene signature
Breast cancers contain a minority population of cancer cells characterized by CD44 expression but low or undetectable levels of CD24 (CD44+CD24-/low) that have higher tumorigenic capacity than other subtypes of cancer cells. METHODS: We compared the gene-expression profile of CD44+CD24-/low tumorige...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-6883 | biostudies-arrayexpress
GenomicsClostridioides difficile CD44
Clostridioides difficile CD44 Genome sequencing and assembly
PRJNA85707 | ENA
TranscriptomicsmiRNA expression profiling in human mammary epithelial cell (HMEC) CD24-CD44+ and non-CD24-CD44+ cell populations
To understand the role of p53 in regulating stem cell population (CD24-CD44+) and stemness-associated miRNAs, we first compared miRNA expression profiles between human mammary epithelical cells knocked-down p53 and control cells. We then cross-referenced p53-regulated miRNAs with stemness-associated...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-25036 | biostudies-arrayexpress
TranscriptomicsDifferences between CD44+/CD24- and CD44-/CD24+ subpopulation of immortalized human mammary epithelial cells
CD44+/CD24- subpopulation of normal and cancerous breast epithelial cells are suggested to have stem cell properties. The goal of this study was to identify gene expression differences between CD44+/CD24- and CD44-/CD24+ subpopulation of cells from a same cell lines. We selected MCF-10A cells, which...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-15192 | biostudies-arrayexpress
ProteomicsCharacterization of CD44s glycoproteoforms in bladder tumours and bladder cancer cell culture models
Bladder cancer (BC) is a major health concern retaining high mortality rates when diagnosed at advanced stages. In this context, the clinical management of BC requires the introduction of new biomarkers and molecular targets capable to elicit precision medicine therapeutical approaches. A promising ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD028307 | Pride
Glycosylation Cd44 Glycoproteogenomics Bladder cancer Alternative splicing 
ProteomicsThe effect of very-high-molecular-mass hyaluronan (vHMM-HA) on CD44 protein-protein interactions.
Naked mole-rat skin fibroblasts (NSF) produces vHMM-HA. Although NSF-HA has been shown to suppress NSF transformation, it is still unclear if exceptional polymer length of vHMM-HA is important for its functions. Here, we compared the effect of intact control NSF-HA (cNSF-HA) and partially fragmented...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD013445 | Pride
Naked mole rat / hyaluronan / cd44 
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