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ProteomicsIL-7 priming in human primary T cells
Characterize the proteome and phosphoproteome changes in primary human T cells upon IL-7 priming
ORGANISM(S): Homo sapiens (Human) 
2022-01-25 | PXD013520 | Pride
Phosphoproteome T cells Il-7 
TranscriptomicsTranscription profiling of human T cells to determine the strength of T cell stimulation
The strength of T cell stimulation determines IL-7 responsiveness, recall potential and lineage commitment of primed human CD4+IL-7Rhi T cells; We analyzed how the strength of antigenic stimulation - as determined by dendritic cell (DC) number, DC maturation state and antigen concentration - control...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6566 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression analysis of alphaCD3alpha/CD28 activated human naive and memory regulatory T cells (Treg) upon IL-7 treatment as measured by quantitative PCR array
This study evaluated changes in gene expression upon IL-7 treatment in human naive and memory Treg. CD4+CD25+CD127low naïve and memory Treg were isolated from fresh PBMC and separately stimulated with ?CD3?/CD28 coupled beads (Invitrogen-Dynal) at a 1:10 bead/T cell ratio, treated with or without 10...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-40755 | biostudies-arrayexpress
TranscriptomicsSuppression of molecular inflammatory pathways by Toll-like Receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation of Toll-like receptors (TLRs) 7, 8 and 9 contributes to the initiation and maintenance of psoriasis. We have evaluated the effects of TLR a...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-50400 | biostudies-arrayexpress
ModelsPalmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signaling
Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. ...
2024-09-02 | BIOMD0000000968 | BioModels
GenomicsTandem bispecific IL-7 receptor agonist antibody
Tandem bispecific IL-7 receptor agonist antibody
PRJNA1327777 | ENA
TranscriptomicsIL-7 and IL-15 instruct the generation of human memory stem T cells from naïve precursors
The identification of the most appropriate T-cell subset to ensure optimal persistence and anti-tumor activity is a major goal of cancer immunotherapy. We identified a novel post-mitotic CD45RA+CD62L+ T cell subpopulation (TTN), generated in vitro upon activation of naïve T (TN) cells with beads con...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-41909 | biostudies-arrayexpress
TranscriptomicsContext-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele
IL-7 is a key factor in T-cell immunity and IL7R polymorphisms are implicated in autoimmune pathogenesis. IL7R mRNA is induced in stimulated monocytes in a genetically determined manner. Here we show monocyte surface and soluble IL7R (sIL7R) protein are markedly expressed in response to lipopolysacc...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-8207 | biostudies-arrayexpress
TranscriptomicsThe Chimeric Oncoprotein TLS-CHOP Represses Expression of the Anticancer Cytokine MDA-7/IL-24 in Myxoid Liposarcoma Cells
The TLS-CHOP fusion protein is found in the majority of human myxoid liposarcomas (MLS), and is thought to have oncogenic functions. Until now, however, the molecular function of TLS-CHOP for oncogenesis is still elusive. In this report, we have revealed that knockdown of TLS-CHOP by specific siRN...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-33616 | biostudies-arrayexpress
ProteomicsIL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation
Homeostatic proliferation, driven by cytokines including IL-7, maintains stable T cell populations over time and expands these during lymphopenia, for example following stem cell transplantation. Yet, impaired T cell expansion in this context is associated with diminished immune protection, whilst e...
ORGANISM(S): Human 
2024-11-27 | MSV000096546 | MassIVE
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