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TranscriptomicsGene expression analysis in proximal and distal colons of Lcn2-/- IL10-/- double knock-out mice.
Lcn2 is involved in host defense against pathogens, but the function in intestinal mucosal immunity and inflammation remains largely unknown. Genetic ablation of Lcn2 results in early-onset colitis and spontaneous emergence of right-sided colonic tumors in the setting of IL-10 deficiency (Lcn2-/-;IL...
ORGANISM(S): Mus musculus 
2016-03-30 | E-MTAB-4583 | biostudies-arrayexpress
TranscriptomicsColon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or Escherichia faecalis OG1RF (PAMM-077 array)
We observed that interleukin-10 knockout (Il10-/-) mice injected with azoxymethane (AOM) and monoassociated with E. coli NC101, but not E. faecalis OG1RF, develop tumors. Histologic inflammation is not different in mice monoassociated with either bacterium. The goal of this experiment is to assess i...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39092 | biostudies-arrayexpress
GenomicsIL10 Chicken Project
16S analysis of caecal contents of IL10 chicken
PRJEB71960 | ENA
TranscriptomicsUnstable Foxp3+ regulatory T cells and altered antigen-presenting cells are associated with lipopolysaccharide-induced fetal loss in pregnant IL10 deficient mice
Maternal IL10 deficiency elevates susceptibility to fetal loss induced by the model Toll-like receptor agonist lipopolysaccharide, but the mechanisms are not well elucidated. Here we show that Il10 null mutant (Il10-/-) mice exhibit altered local T cell responses in pregnancy, exhibiting pronounced ...
ORGANISM(S): Mus musculus 
2015-07-30 | E-GEOD-71494 | biostudies-arrayexpress
GenomicsComparison of IL10-eGFP+ cells with IL10-eGFP- CD4+ T cells induced by in vivo immunisation
Comparison of IL10-eGFP+ cells with IL10-eGFP- CD4+ T cells induced by in vivo immunisation
PRJNA1193044 | ENA
TranscriptomicsTranscription profiling of mouse colon from interleukin-10 gene-deficient mice
A total of 30 male IL10-/- (B6.129P2-Il10/J) and 30 male C57 control (C57BL/6J) mice were obtained from The Jackson Laboratory (Bar Harbor, Maine, USA). All mice were between 28 and 35 days of age at the start of the study. For convenience and consistency in reporting, their age was defined ...
ORGANISM(S): Mus musculus 
2009-09-18 | E-GEOD-17990 | biostudies-arrayexpress
TranscriptomicsIdentification of pathways and transcription factors relevant to gut inflammation and anti-inflammatory probiotics
Using Affymetrix data analysis, important signalling pathways and transcription factors relevant to gut inflammation and anti-inflammatory action of probiotics were identified using the clinically validated probiotic VSL#3 and the IL10-knockout mouse, an animal model for inflammatory bowel disease. ...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-13819 | biostudies-arrayexpress
TranscriptomicsColon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or NC101-delta-pks
We observed that deletion of polyketide synthase (pks) from E. coli NC101 reduces its ability to induce tumors in interleukin-10 knockout (Il10-/-) mice injected with azoxymethane (AOM), without altering histologic inflammation. The goal of this experiment is to assess inflammatory cytokine levels i...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39095 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Il10-/- mutants treated with dietary eicosapentaenoic acid (EPA) to investigate intestinal inflammation
Dietary n-3 polyunsaturated fatty acids can reduce inflammation via a range of mechanisms. This study tested the effect of dietary eicosapentaenoic acid (EPA) on intestinal inflammation using interleukin-10 gene-deficient (Il10-/-) mice. Methods: At 35 days of age, 12 weaned Il10-/- and 12 C57 mice ...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-12028 | biostudies-arrayexpress
TranscriptomicsColon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or Escherichia faecalis OG1RF (PAMM-073 array)
We observed that interleukin-10 knockout (Il10-/-) mice injected with azoxymethane (AOM) and monoassociated with E. coli NC101, but not E. faecalis OG1RF, develop tumors. Histologic inflammation is not different in mice monoassociated with either bacterium. The goal of this experiment is to assess i...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39094 | biostudies-arrayexpress
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