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GenomicsIL11 is elevated in systemic sclerosis and IL11-dependent ERK signaling is needed for the profibrotic activity of TGFβ in dermal fibroblasts
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signaling is needed for the profibrotic activity of TGFβ in dermal fibroblasts
PRJNA683969 | ENA
ProteomicsCytokine signaling converging on IL11 signalling in ILD fibroblasts induces aberrant epithelial differentiation signatures
Fibrotic interstitial lung disease (ILD) are lung disorders characterized by the accumulation of extracellular matrix, ultimately resulting in the destruction of the pulmonary scaffold. Continuous pro-fibrotic signaling perpetuates the remodeling process, specifically targeting the epithelial cell c...
ORGANISM(S): Homo sapiens (Human) 
2023-04-19 | PXD039554 | Pride
Cytokine Interstitial lung disease Organoids Co-culture model Il11 Disease modeling Secretome Human pluripotent stem cells 
GenomicsCardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction
Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction
PRJNA992522 | ENA
UnknownIL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.
Not available
S-EPMC8645270 | biostudies-literature
TranscriptomicsIL11 is elevated in systemic sclerosis and IL11-dependent ERK signaling is needed for the profibrotic activity of TGFβ in dermal fibroblasts
Objectives: Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts from patients with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with human dermal fibroblast (HDF) activation. Methods: We measured serum IL11 levels in healthy volunteers and pati...
ORGANISM(S): Homo sapiens 
2021-02-22 | GSE162966 | GEO
UnknownColitis-induced IL11 promotes colon carcinogenesis.
Not available
S-EPMC8086771 | biostudies-literature
GenomicsIL11 organizes a macrotrabecular structure with immune evasion in aggressive hepatocellular carcinoma
IL11 organizes a macrotrabecular structure with immune evasion in aggressive hepatocellular carcinoma
PRJNA925802 | ENA
TranscriptomicsCardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction
Background: Cardiac fibrosis is a common pathological process in heart disease and represents a therapeutic target. TGFβ is the canonical driver of cardiac fibrosis and was recently shown to be dependent on IL11 for its profibrotic effects in fibroblasts. In the opposite direction, recombinant human...
ORGANISM(S): Mus musculus 
2023-08-21 | GSE236854 | GEO
UnknownIL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues.
Not available
S-EPMC9408968 | biostudies-literature
UnknownCardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.
Not available
S-EPMC10455677 | biostudies-literature
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